ArticleThe Journal of antimicrobial chemotherapy2007
Antibiotics for the eradication of Propionibacterium acnes biofilms in surgical infection.
Article in The Journal of antimicrobial chemotherapy, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 87 citations in OpenAlex.
- [Antimicrobial therapy of periprosthetic joint infection : Full version of the AE guidelines (2026)].Orthopadie (Heidelberg, Germany) · 2026Review
- Cutibacterium Adaptation to Life on Humans Provides a Potential C acnes Infection Biomarker.The Journal of investigative dermatology · 2026Article
- Detection of Cutibacterium (Propionibacterium) acnes in orthopaedic surgery: serious problem or contamination?International orthopaedics · 2024Article
- Successful Treatment ofOpen forum infectious diseases · 2023Article
- Review
- The hero of American and Polish nations: a molecular look at Thaddeus Kosciuszko's cause of death suggests a contribution of endocarditis caused by Cutibacterium acnes infection.Microbial cell factories · 2022Article
- Clindamycin Efficacy forAntibiotics (Basel, Switzerland) · 2022Article
- Breast Implant Illness andPlastic and reconstructive surgery. Global open · 2022Article
- Article
- Article
- Bilateral native knee septic arthritis due toClinical case reports · 2019Article
- Indolent Propionibacterium acnes infection associated with orthopedic hardware in the ankle: A case report and literature review.Clinical case reports · 2019Article
- Article
- Theoretical investigation of stochastic clearance of bacteria: first-passage analysis.Journal of the Royal Society, Interface · 2019Article
- Investigation and Management of Periprosthetic Joint Infection in the Shoulder and Elbow: Evidence and consensus based guidelines of the British Elbow and Shoulder Society.Shoulder & elbow · 2018Article
- Article
- Orthopedic implant-associated infections caused by Cutibacterium spp. - A remaining diagnostic challenge.PloS one · 2018Article
- Anaerobic bacteria growth in the presence of cathelicidin LL-37 and selected ceragenins delivered as magnetic nanoparticles cargo.BMC microbiology · 2017Article
- Article
- Which is the best treatment for prosthetic joint infections due to Propionibacterium acnes: need for further biofilm in vitro and experimental foreign-body in vivo studies?Acta orthopaedica · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesPropionibacterium acnes is increasingly recognized as a cause of delayed infection after spinal instrumentation or shunting for hydrocephalus. Biofilm development by this organism has recently been demonstrated. We therefore investigated the effect of two different courses of three antibiotics (penicillin, rifampicin and linezolid) on mature P. acnes biofilms in vitro. Outcomes were eradication or regrowth after withdrawal of antibiotics, simulating successful treatment and relapse.
methodsP. acnes biofilms were grown on titanium discs for 6 days until mature, then exposed to the antibiotics for either 7 or 14 days before sonication and culture. Further, discs were similarly exposed, but after each course, they were reincubated for a further 9 days to check for regrowth.
resultsPenicillin, linezolid and linezolid plus rifampicin eradicated P. acnes biofilms after 14 days, but only penicillin had this effect after 7 days. 'Relapse' was prevented only by 14 day courses of penicillin or linezolid plus rifampicin, but not by linezolid alone.
conclusionsFor P. acnes spinal instrumentation infections, either penicillin or linezolid plus rifampicin might be equally effective. For shunt infections, as penicillin does not give therapeutic cerebrospinal fluid concentrations, rifampicin plus linezolid might be the treatment of choice. Linezolid alone appears not to be as effective as penicillin against P. acnes biofilms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.