ReviewJournal of autoimmunity2007
Toll like receptors and autoimmunity: a critical appraisal.
Review in Journal of autoimmunity, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed.
- Herbal supplement Spirulina stimulates inflammatory cytokine production in patients with dermatomyositisiScience · 2023Article
- Review
- Association of Single Nucleotide Polymorphisms from Angiogenesis-Related Genes,Current issues in molecular biology · 2022Article
- Impaired Innate Immunity in Pediatric Patients Type 1 Diabetes-Focus on Toll-like Receptors Expression.International journal of molecular sciences · 2021Article
- Synergistic Activation of Toll-Like and NOD Receptors by Complementary Antigens as Facilitators of Autoimmune Disease: Review, Model and Novel Predictions.International journal of molecular sciences · 2020Review
- The Role of TLR4 Asp299Gly and TLR4 Thr399Ile Polymorphisms in the Pathogenesis of Urinary Tract Infections: First Evaluation in Infants and Children of Greek Origin.Journal of immunology research · 2019Article
- Small-molecule inhibition of TLR8 through stabilization of its resting state.Nature chemical biology · 2018Article
- Review
- Relevant genetic polymorphisms and kidney expression of Toll-like receptor (TLR)-5 and TLR-9 in lupus nephritis.Clinical and experimental immunology · 2017Article
- Understanding the dynamics of Toll-like Receptor 5 response to flagellin and its regulation by estradiol.Scientific reports · 2017Article
- Increased Abundance of Plasmacytoid Dendritic Cells and Interferon-Alpha Induces Plasma Cell Differentiation in Patients of IgA Nephropathy.Mediators of inflammation · 2017Article
- The Role of Toll-Like Receptors in Autoimmune Diseases through Failure of the Self-Recognition Mechanism.International journal of inflammation · 2017Review
- Toll-Like Receptors in the Pathogenesis of Autoimmune Diseases.Advanced pharmaceutical bulletin · 2015Review
- TLR3/TRIF signalling pathway regulates IL-32 and IFN-β secretion through activation of RIP-1 and TRAF in the human cornea.Journal of cellular and molecular medicine · 2015Article
- Toll-like receptors expression in follicular cells of patients with poor ovarian response.International journal of fertility & sterility · 2014Article
- Expression of toll-like receptors 3, 7, and 9 in peripheral blood mononuclear cells from patients with systemic lupus erythematosus.Mediators of inflammation · 2014Article
- Nucleic Acid sensors and type I interferon production in systemic lupus erythematosus.Frontiers in immunology · 2013Review
- TLR9 deficiency promotes CD73 expression in T cells and diabetes protection in nonobese diabetic mice.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Toxoplasma gondii: bystander or cofactor in rheumatoid arthritis.Immunologic research · 2013Article
- Allelic variants in TLR10 gene may influence bilateral affectation and clinical course of Meniere's disease.Immunogenetics · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is a constant interplay between the innate and adaptive immune systems, which leads to a protective immune response against pathogens and contributes effectively to self-non-self discrimination. Toll-like receptors (TLRs) are key components of the innate immune system, which activate multiple inflammatory pathways and coordinate systemic defense against pathogens. In addition to recognizing unique molecular patterns associated with different classes of pathogens, TLRs may also recognize a number of self proteins and endogenous nucleic acids. Data originating predominantly from animal models of autoimmune disease and circumstantial data from human patients suggest that inappropriate activation of TLR pathways by endogenous or exogenous ligands may lead to the initiation and/or perpetuation of autoimmune responses and tissue injury.
Indexed as
Identifiers
17959357What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.