ArticleJournal of molecular and cellular cardiology2007
Rapid attenuation of circadian clock gene oscillations in the rat heart following ischemia-reperfusion.
Article in Journal of molecular and cellular cardiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 62 citations in OpenAlex.
- Role of circadian transcription factor REV-ERB in cardiovascular diseases: a review.Frontiers in cardiovascular medicine · 2025Review
- Circadian Rhythms in Cardiovascular Metabolism.Circulation research · 2024Review
- The Cardiac Circadian Clock: Implications for Cardiovascular Disease and its Treatment.JACC. Basic to translational science · 2023Review
- The Circadian Biology of Heart Failure.Circulation research · 2023Review
- Carbon monoxide signaling and soluble guanylyl cyclase: Facts, myths, and intriguing possibilities.Biochemical pharmacology · 2022Review
- The Protective Role of Bmal1-Regulated Autophagy Mediated by HDAC3/SIRT1 Pathway in Myocardial Ischemia/Reperfusion Injury of Diabetic Rats.Cardiovascular drugs and therapy · 2022Article
- Interactions between remote ischemic conditioning and post-stroke sleep regulation.Frontiers of medicine · 2021Review
- Article
- Impact of obesity on day-night differences in cardiac metabolism.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Roles of HDAC3-orchestrated circadian clock gene oscillations in diabetic rats following myocardial ischaemia/reperfusion injury.Cell death & disease · 2021Article
- Circadian Clock-Controlled Checkpoints in the Pathogenesis of Complex Disease.Frontiers in genetics · 2021Review
- Bmal1 Regulates the Redox Rhythm of HSPB1, and Homooxidized HSPB1 Attenuates the Oxidative Stress Injury of Cardiomyocytes.Oxidative medicine and cellular longevity · 2021Article
- Complexities in cardiovascular rhythmicity: perspectives on circadian normality, ageing and disease.Cardiovascular research · 2019Review
- Circadian rhythms and the molecular clock in cardiovascular biology and disease.Nature reviews. Cardiology · 2019Review
- An overview of the emerging interface between cardiac metabolism, redox biology and the circadian clock.Free radical biology & medicine · 2018Review
- Carbon monoxide protects the kidney through the central circadian clock and CD39.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- The rat cerebral vasculature exhibits time-of-day-dependent oscillations in circadian clock genes and vascular function that are attenuated following obstructive sleep apnea.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- Circadian clock and the onset of cardiovascular events.Hypertension research : official journal of the Japanese Society of Hypertension · 2016Review
- The role of clock genes and circadian rhythm in the development of cardiovascular diseases.Cellular and molecular life sciences : CMLS · 2015Review
- Regulation of myocardial metabolism by the cardiomyocyte circadian clock.Journal of molecular and cellular cardiology · 2013Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
The intracellular circadian clock consists of a series of transcriptional modulators that together allow the cell to perceive the time of day. Circadian clocks have been identified within various components of the cardiovascular system (e.g. cardiomyocytes, vascular smooth muscle cells) and possess the potential to regulate numerous aspects of cardiovascular physiology and pathophysiology. The present study tested the hypothesis that ischemia/reperfusion (I/R; 30 min occlusion of the rat left main coronary artery in vivo) alters the circadian clock within the ischemic, versus non-ischemic, region of the heart. Left ventricular anterior (ischemic) and posterior (non-ischemic) regions were isolated from I/R, sham-operated, and naïve rats over a 24-h period, after which mRNAs encoding for both circadian clock components and known clock-controlled genes were quantified. Circadian clock gene oscillations (i.e. peak-to-trough fold differences) were rapidly attenuated in the I/R, versus the non-ischemic, region. Consistent with decreased circadian clock output, we observe a rapid induction of E4BP4 in the ischemic region of the heart at both the mRNA and protein levels. In contrast with I/R, chronic (1 week) hypobaric chamber-induced hypoxia did not attenuate oscillations in circadian clock genes in either the left or right ventricle of the rat heart. In conclusion, these data show that in a rodent model of myocardial I/R, circadian clocks within the ischemic region become rapidly impaired, through a mechanism that appears to be independent of hypoxia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.