ArticleJournal of natural products2007
Cytotoxic metabolites from an Indonesian sponge Lendenfeldia sp.
Article in Journal of natural products, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Marine Natural Products From Indonesia and Their Biosynthetic Origins: Part 1: Terpenoids and Meroterpenoids.Chemistry & biodiversity · 2026Review
- Marine-Derived Leads as Anticancer Candidates by Disrupting Hypoxic Signaling through Hypoxia-Inducible Factors Inhibition.Marine drugs · 2024Review
- Recent advances in oxidative phenol coupling for the total synthesis of natural products.Natural product reports · 2024Review
- Nor-24-homoscalaranes, Neutrophilic Inflammatory Mediators from the Marine SpongePharmaceuticals (Basel, Switzerland) · 2023Article
- Scalarane-Type Sesterterpenoids from the Marine SpongeMarine drugs · 2021Article
- Sponge-Derived 24-Homoscalaranes as Potent Anti-Inflammatory Agents.Marine drugs · 2020Article
- Marine Natural Products from Indonesian Waters.Marine drugs · 2019Review
- Scalalactams A⁻D, Scalarane Sesterterpenes with a γ-Lactam Moiety from a Korean Spongia Sp. Marine Sponge.Molecules (Basel, Switzerland) · 2018Article
- Marine sponge derived natural products between 2001 and 2010: trends and opportunities for discovery of bioactives.Marine drugs · 2014Review
- Structural reassignment of a marine metabolite from a binaphthalenetetrol to a tetrabrominated diphenyl ether.Journal of natural products · 2012Article
- Marine Natural Products as Inhibitors of Hypoxic Signaling in Tumors.Phytochemistry reviews : proceedings of the Phytochemical Society of Europe · 2009Article
- Molecular-targeted antitumor agents. 19. Furospongolide from a marine Lendenfeldia sp. sponge inhibits hypoxia-inducible factor-1 activation in breast tumor cells.Journal of natural products · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The lipid extract of an Indonesian Lendenfeldia sp. sponge inhibited hypoxia-induced hypoxia-inducible factor-1 (HIF-1) activation in T47D breast tumor cells. Chromatographic separation yielded the new substituted naphthalene dimer 1, the new furanolipid 2, and three known homoscalarane sesterterpenes, 3-5. Compounds 1 and 3-5 inhibited hypoxia-induced HIF-1 activation (IC50 values: 0.64-6.9 microM), but also reduced the viability of T47D and MDA-MB-231 breast tumor cells. Compound 4 was the most potent and showed a unique tumor cell line selectivity in the NCI 60-cell line panel. The general cytotoxicity of these compounds precluded their further consideration as HIF-1 inhibitors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.