ArticlePediatric nephrology (Berlin, Germany)2008
Evaluation of activity, chronicity and tubulointerstitial indices for childhood lupus nephritis.
Article in Pediatric nephrology (Berlin, Germany), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 52 citations in OpenAlex.
- Pathogenesis, Treatment Advances, and Renal Outcomes in Childhood-Onset Lupus Nephritis.Clinical pediatrics · 2026Review
- Do we really need cyclophosphamide for lupus nephritis?Pediatric nephrology (Berlin, Germany) · 2024Article
- Development of clinical and laboratory biomarkers in an international cohort of 428 children with lupus nephritis.Pediatric nephrology (Berlin, Germany) · 2024Article
- Urine biomarker score captures response to induction therapy with lupus nephritis.Pediatric nephrology (Berlin, Germany) · 2023Article
- Tertiary lymphoid tissues in kidney diseases: a perspective for the pediatric nephrologist.Pediatric nephrology (Berlin, Germany) · 2023Review
- Article
- Change of Renal Gallium Uptake Correlated with Change of Inflammation Activity in Renal Pathology in Lupus Nephritis Patients.Journal of clinical medicine · 2021Article
- Kidney outcomes for children with lupus nephritis.Pediatric nephrology (Berlin, Germany) · 2021Review
- Clinicopathological factors for tubulointerstitial injury in lupus nephritis.Clinical rheumatology · 2020Article
- Spectrum of systemic lupus erythematosus in Oman: from childhood to adulthood.Rheumatology international · 2018Article
- Redefining lupus nephritis: clinical implications of pathophysiologic subtypes.Nature reviews. Nephrology · 2017Review
- Advances in the care of children with lupus nephritis.Pediatric research · 2017Review
- Serum IL-18 as biomarker in predicting long-term renal outcome among pediatric-onset systemic lupus erythematosus patients.Medicine · 2016Article
- Development of a Novel Renal Activity Index of Lupus Nephritis in Children and Young Adults.Arthritis care & research · 2016Article
- Validation of the Lupus Nephritis Clinical Indices in Childhood-Onset Systemic Lupus Erythematosus.Arthritis care & research · 2016Article
- Diagnosis and Management of Multiple Sclerosis in Children.Iranian journal of child neurology · 2016Review
- Long-term renal outcomes of childhood-onset global and segmental diffuse proliferative lupus nephritis.Pediatric nephrology (Berlin, Germany) · 2015Article
- Practice patterns and approach to kidney biopsy in lupus: a collaboration of the Midwest Pediatric Nephrology Consortium and the Childhood Arthritis and Rheumatology Research Alliance.Pediatric rheumatology online journal · 2015Article
- Biomarkers and updates on pediatrics lupus nephritis.Rheumatic diseases clinics of North America · 2013Review
- Update on differences between childhood-onset and adult-onset systemic lupus erythematosus.Arthritis research & therapy · 2013Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Few data exist on use of the National Institutes of Health (NIH) activity index (AI) and chronicity index (CI) in childhood lupus nephritis (LN). A tubulointerstitial activity index (TIAI) has been derived but not validated. We evaluated clinicopathologic correlations of the AI, CI and TIAI in children with LN who had undergone initial renal biopsy (n=25, age 12.4+/-2.7 years, biopsy 1) and 1 year after treatment (n=15, biopsy 2). The TIAI correlated with the AI at biopsy 1 (r=0.76, P=0.001) and biopsy 2 (r=0.52, P=0.05), but not with CI scores. Mean AI and CI scores changed substantially from biopsy 1 to biopsy 2 (P<0.05), but TIAI scores did not. Higher AI and TIAI scores correlated with proteinuria at both biopsies (r=0.51-0.76, P<0.05); CI scores correlated with estimated creatinine clearance (r=0.46-0.58, P<0.05). Improved AI score from biopsy 1 to biopsy 2 was associated with decrease in proteinuria. These results suggest that the AI and CI are useful in childhood LN. The TIAI may be a valid measure to evaluate the tubulointerstitium, but research is needed to define its responsiveness to change with therapy.
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