ReviewCritical reviews in oncogenesis2007
Epigenetic transgenerational actions of vinclozolin on the development of disease and cancer.
Review in Critical reviews in oncogenesis, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 47 citations in OpenAlex.
- The effect of chronic inflammation on female fertility.Reproduction (Cambridge, England) · 2025Review
- Adaptive Significance of Non-coding RNAs: Insights from Cancer Biology.Molecular biology and evolution · 2025Review
- Inheritance of paternal lifestyles and exposures through sperm DNA methylation.Nature reviews. Urology · 2023Review
- Role of epigenetic transgenerational inheritance in generational toxicology.Environmental epigenetics · 2022Review
- Analysis of the impact of three phthalates on the freshwater gastropod Physella acuta at the transcriptional level.Scientific reports · 2021Article
- Environmental and socio-cultural impacts on global DNA methylation in the indigenous Huichol population of Nayarit, Mexico.Environmental science and pollution research international · 2021Article
- Paternal morphine exposure induces bidirectional effects on cocaine versus opioid self-administration.Neuropharmacology · 2020Article
- Review
- Role of Plastics on Human Health.Indian journal of pediatrics · 2018Article
- Environmentally induced epigenetic transgenerational inheritance of disease.Environmental epigenetics · 2018Review
- High pesticide exposure events and DNA methylation among pesticide applicators in the agricultural health study.Environmental and molecular mutagenesis · 2017Article
- Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead.Carcinogenesis · 2015Review
- Environmental immune disruptors, inflammation and cancer risk.Carcinogenesis · 2015Review
- Genome-wide study of DNA methylation alterations in response to diazinon exposure in vitro.Environmental toxicology and pharmacology · 2012Article
- DNA methylation alterations in response to pesticide exposure in vitro.Environmental and molecular mutagenesis · 2012Article
- Article
- Components of plastic: experimental studies in animals and relevance for human health.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Exposure to an environmental endocrine disruptor (e.g., vinclozolin) during embryonic gonadal sex determination appears to alter the male germ line epigenome and subsequently promotes transgenerational adult onset disease. The epigenetic mechanism involves the induction of new imprinted-like genes/DNA sequences in the germ line that appear to transmit disease phenotypes. The disease phenotypes include testis abnormalities, prostate disease, kidney disease, immune abnormalities, and tumor development. This epigenetic transgenerational disease mechanism provides a unique perspective from which to view inheritable adult onset disease states, such as cancer, and ultimately offers new insights into novel diagnostic and therapeutic strategies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.