ArticleNeuroradiology2007
Precuneus atrophy in early-onset Alzheimer's disease: a morphometric structural MRI study.
Article in Neuroradiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers.
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Who cites it
143 citing papers in PubMed, 298 citations in OpenAlex.
- Neuroplastic effects of combined computerized physical and cognitive training in elderly individuals at risk for dementia: an eLORETA controlled study on resting states.Neural plasticity · 2015Trial
- Explainable machine learning identifies candidate shared neuroanatomical features in Alzheimer's and Parkinson's via importance inversion transfer.bioRxiv : the preprint server for biology · 2026Article
- Modulating the default mode network with deep TMS: a proof-of-concept framework with potential relevance to circuits implicated in lack of awareness of cognitive decline.Frontiers in aging neuroscience · 2026Article
- Morphological variations and cortical atrophy of the precuneus in normal aging and Alzheimer's disease.Journal of anatomy · 2026Article
- Growth and development of the precuneus in humans from birth to early adulthood.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Brain Topology Disruption in Early-Onset Dementia: Review of Current Findings and the Need for Network Resilience Focused Models.Brain and behavior · 2025Review
- Investigating the associations between tau and mental orientation among cognitively unimpaired individuals.Journal of Alzheimer's disease : JAD · 2025Article
- An interpretable generative multimodal neuroimaging-genomics framework for decoding Alzheimer's disease.Journal of neural engineering · 2025Article
- White matter hyperintensities and their impact in brain structure and function in alzheimer's disease and behavioral variant frontotemporal dementia across Latin America and the United States: a cross-sectional study.Alzheimer's research & therapy · 2025Article
- Association of magnetic resonance imaging glymphatic function with gray matter volume loss and cognitive impairment in Alzheimer's disease: a diffusion tensor image analysis along the perivascular space (DTI-ALPS) study.Quantitative imaging in medicine and surgery · 2025Article
- Mapping the impact of age and APOE risk factors for late onset Alzheimer's disease on long range brain connections through multiscale bundle analysis.Brain structure & function · 2025Article
- The association between precuneus cortex thickness and mild behavioral impairment in patients with mild stroke.Brain imaging and behavior · 2025Article
- Alzheimer's disease recognition via long-range state space model using multi-modal brain images.Frontiers in neuroscience · 2025Article
- Altered dynamic functional network connectivity patterns in Alzheimer's disease: insights into neural dysfunction.Frontiers in aging neuroscience · 2025Article
- Cognitive impact and brain structural changes in long COVID patients: a cross-sectional MRI study two years post infection in a cohort from Argentina.BMC neurology · 2024Article
- Detection of Alzheimer's Disease Using Hybrid Meta-ROI of MRI Structural Images.Diagnostics (Basel, Switzerland) · 2024Article
- Mapping the impact of age and APOE risk factors for late onset Alzheimer's disease on long range brain connections through multiscale bundle analysis.bioRxiv : the preprint server for biology · 2024Article
- Automated detection of Alzheimer's disease: a multi-modal approach with 3D MRI and amyloid PET.Scientific reports · 2024Article
- Neuroprotective effects of repetitive transcranial magnetic stimulation on Alzheimer's disease: Undetermined therapeutic protocols and mechanisms.Neuroprotection (Chichester, England) · 2024Review
- Novel Biomarkers for Alzheimer's Disease: Plasma Neurofilament Light and Cerebrospinal Fluid.International journal of Alzheimer's disease · 2024Review
83 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAlzheimer's disease (AD) usually first presents in elderly patients, but may also develop at an earlier age. Patients with an early age at onset tend to present with complaints other than memory impairment, such as visuospatial problems or apraxia, which may reflect a different distribution of cortical involvement. In this study we set out to investigate whether age at onset in patients with AD determines the pattern of atrophy on cerebral MRI scans.
methodsWe examined 55 patients with AD over a wide age range and analyzed their 3-D T1-weighted structural MRI scans in standard space using voxel-based morphometry (VBM). Regression analysis was performed to estimate loss of grey matter as a function of age, corrected for mini-mental state examination (MMSE) scores and sex.
resultsThe VBM analyses identified multiple areas (including the temporal and parietal lobes), showing more atrophy with advancing age. By contrast, a younger age at onset was found to be associated with lower grey matter density in the precuneus. Regionalized volumetric analysis of this region confirmed the existence of disproportionate atrophy in the precuneus in patients with early-onset AD. Application of a multivariate model with precuneus grey matter density as input, showed that precuneal and hippocampal atrophy are independent from each other. Additionally, we found that a smaller precuneus is associated with impaired visuospatial functioning.
conclusionOur findings support the notion that age at onset modulates the distribution of cortical involvement, and that disproportionate precuneus atrophy is more prominent in patients with a younger age of onset.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.