ReviewMedGenMed : Medscape general medicine2007
Nocturnal hypoglycemia: answering the challenge with long-acting insulin analogs.
Review in MedGenMed : Medscape general medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Dietary intake and risk of non-severe hypoglycemia in adolescents with type 1 diabetes.Journal of diabetes and its complications · 2017Trial
- Insulin degludec versus insulin glargine in insulin-naive patients with type 2 diabetes: a 1-year, randomized, treat-to-target trial (BEGIN Once Long).Diabetes care · 2012Trial
- Efficacy and safety of once-weekly insulin efsitora alfa versus daily basal insulin analogs in type 2 diabetes: a systematic review and meta-analysis.Annals of medicine and surgery (2012) · 2026Article
- Multimodal Physiological Monitoring Using Novel Wearable Sensors: A Pilot Study on Nocturnal Glucose Dynamics and Meal-Related Cardiovascular Responses.Bioengineering (Basel, Switzerland) · 2026Article
- Transforming hypoglycemia prediction in adult type 1 diabetes: a systematic review and meta-analysis for precision care.Open life sciences · 2026Article
- Combining uncertainty-aware predictive modeling and a bedtime Smart Snack intervention to prevent nocturnal hypoglycemia in people with type 1 diabetes on multiple daily injections.Journal of the American Medical Informatics Association : JAMIA · 2023Article
- Persistent Postgastrectomy Hypoglycemia Unawareness in Patients With Gastric Cancer Unveiled by a Prospective Study.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2022Article
- Ability of Current Machine Learning Algorithms to Predict and Detect Hypoglycemia in Patients With Diabetes Mellitus: Meta-analysis.JMIR diabetes · 2021Article
- Predicting and Preventing Nocturnal Hypoglycemia in Type 1 Diabetes Using Big Data Analytics and Decision Theoretic Analysis.Diabetes technology & therapeutics · 2020Article
- Basal insulin therapy: Unmet medical needs in Asia and the new insulin glargine in diabetes treatment.Journal of diabetes investigation · 2019Review
- Nocturnal Glycemic Control with New Insulin Glargine 300 U/mL.Advances in medicine · 2019Article
- Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?Case reports in endocrinology · 2018Article
- Challenges and unmet needs in basal insulin therapy: lessons from the Asian experience.Diabetes, metabolic syndrome and obesity : targets and therapy · 2017Review
- Concepts and clinical use of ultra-long basal insulin.Diabetology & metabolic syndrome · 2016Review
- Identifying and meeting the challenges of insulin therapy in type 2 diabetes.Journal of multidisciplinary healthcare · 2014Review
- Diabetes management: optimizing roles for nurses in insulin initiation.Journal of multidisciplinary healthcare · 2011Article
- Long-Acting Insulin Analogues for the Treatment of Diabetes Mellitus: Meta-analyses of Clinical Outcomes.CADTH technology overviews · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNocturnal hypoglycemia may be the most common type of hypoglycemia in individuals with diabetes using insulin and is particularly worrisome because it often goes undetected and may lead to unconsciousness and even death in severe cases.
objectivesThe prevalence, causes, and consequences of nocturnal hypoglycemia as well as detection and prevention strategies are reviewed, including the use of long-acting insulin analogs, which offer more physiologic and predictable time-action profiles than traditional human basal insulin. DATA SOURCES: A total of 307 publications (151 PubMed; 104 Adis; 52 BIOSIS) were reviewed. REVIEW
methodsRelevant trials were found by searching for "(detemir OR glargine) AND nocturnal AND (hypoglycemia OR hypoglycaemia) AND diabetes." To capture trials that may not have specified "nocturnal" in the title or abstract text but still reported nocturnal hypoglycemia data, a supplemental search of PubMed using "(detemir OR glargine) AND (nocturnal OR hypoglycemia OR hypoglycaemia) AND diabetes" was undertaken.
resultsA review of these trials found that patients with type 1 and type 2 diabetes mellitus have a lower risk for nocturnal hypoglycemia when receiving long-acting insulin analogs (insulin detemir or insulin glargine), provided that glycemic control is comparable to that provided by traditional human basal insulin. Long-acting insulin analogs may be the best option to provide basal insulin coverage in patients who do not choose or require continuous subcutaneous insulin infusion.
conclusionsRandomized clinical trials suggest that the long-acting insulin analogs are associated with a lower risk for nocturnal hypoglycemia than neutral protamine Hagedorn without sacrificing glycemic control.
Indexed as
Identifiers
17955093PMC1994862W1482950896What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.