ReviewMedGenMed : Medscape general medicine2007
An evidence-based algorithm for the treatment of neuropathic pain.
Review in MedGenMed : Medscape general medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Interventions for treating pain and disability in adults with complex regional pain syndrome.The Cochrane database of systematic reviews · 2013Pooled it
- Interventions to improve the use of systematic reviews in decision-making by health system managers, policy makers and clinicians.The Cochrane database of systematic reviews · 2012Pooled it
- Repetitive Transcranial Magnetic Stimulation for Phantom Limb Pain in Land Mine Victims: A Double-Blinded, Randomized, Sham-Controlled Trial.The journal of pain · 2016Trial
- Is altered central pain processing related to disease stage in chronic pancreatitis patients with pain? An exploratory study.PloS one · 2013Trial
- Topical 5% lidocaine (lignocaine) medicated plaster treatment for post-herpetic neuralgia: results of a double-blind, placebo-controlled, multinational efficacy and safety trial.Clinical drug investigation · 2009Trial
- Efficacy and safety of 5% lidocaine (lignocaine) medicated plaster in comparison with pregabalin in patients with postherpetic neuralgia and diabetic polyneuropathy: interim analysis from an open-label, two-stage adaptive, randomized, controlled trial.Clinical drug investigation · 2009Trial
- Mechanisms for reducing/eliminating chronic neuropathic pain with a focus on platelet-rich plasma.Experimental biology and medicine (Maywood, N.J.) · 2025Review
- Treatment Analysis of Patients Followed up With Postherpetic Neuralgia in Nothern Cyprus.Materia socio-medica · 2022Article
- Treatment Recommendations for Phantom Limb Pain in People with Amputations: An Expert Consensus Delphi Study.PM & R : the journal of injury, function, and rehabilitation · 2021Article
- Nonlinear Relation Between Burst Dorsal Root Ganglion Stimulation Amplitude and Behavioral Outcome in an Experimental Model of Painful Diabetic Peripheral Neuropathy.Neuromodulation : journal of the International Neuromodulation Society · 2020Article
- Frontiers in Pain Research: A Scope of Its Focus and Content.Frontiers in pain research (Lausanne, Switzerland) · 2020Article
- Dorsal Root Ganglion Stimulation in Experimental Painful Diabetic Peripheral Neuropathy: Burst vs. Conventional Stimulation Paradigm.Neuromodulation : journal of the International Neuromodulation Society · 2019Article
- Yoga: Can it be integrated with treatment of neuropathic pain?Annals of neurosciences · 2019Review
- Efficacy of a Combination of N-Palmitoylethanolamide, Beta-Caryophyllene, Carnosic Acid, and Myrrh Extract on Chronic Neuropathic Pain: A Preclinical Study.Frontiers in pharmacology · 2019Article
- Evidence of central sensitisation in those with dry eye symptoms and neuropathic-like ocular pain complaints: incomplete response to topical anaesthesia and generalised heightened sensitivity to evoked pain.The British journal of ophthalmology · 2017Article
- Opioid Prescribing at Hospital Discharge Contributes to Chronic Opioid Use.Journal of general internal medicine · 2016Article
- Treatment of localized neuropathic pain of different etiologies with the 5% lidocaine medicated plaster - a case series.International journal of general medicine · 2015Article
- Drug combinations in the treatment of neuropathic pain.Current pain and headache reports · 2014Review
- Cancer treatment-related neuropathic pain syndromes--epidemiology and treatment: an update.Current pain and headache reports · 2014Review
- Pharmacological management of depression in patients with cancer: practical considerations.Drugs · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe purpose of this article is to discuss an evidence-based algorithm that can be implemented by the primary care physician in his/her daily clinical practice for the treatment of patients with neuropathic pain conditions.
methodA treatment algorithm for neuropathic pain was formulated on the basis of a review of 105 high-quality, randomized, placebo-controlled clinical trials. The number needed to treat (NNT) and number needed to harm (NNH) were used to compare the safety and effectiveness of current treatments for neuropathic pain syndromes. Most of the clinical trials reviewed in the analysis assessed tricyclic antidepressants (TCAs) and antiepileptic drugs (AEDs).
resultsTCAs had the lowest NNT followed by opioids and AEDs, such as gabapentin and pregabalin. The nature of the retrospective calculation of the NNT and NNH involves obvious limitations because of the pooling of studies with different experimental designs and outcomes.
conclusionPatients presenting with neuropathic pain are becoming a more frequent occurrence for the primary care physician as the population ages. Evidence-based treatment options allow for the most efficient and effective pharmacotherapy regimen to be implemented.
Indexed as
Identifiers
17955091PMC1994866What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.