ArticleRadiology2007
Blood vessel morphologic changes depicted with MR angiography during treatment of brain metastases: a feasibility study.
Article in Radiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 43 citations in OpenAlex.
- Phase II trial of carboplatin and bevacizumab in patients with breast cancer brain metastases.Breast cancer research : BCR · 2020Trial
- Detection of cervical lymph node metastasis from oral cavity cancer using a non-radiating, noninvasive digital infrared thermal imaging system.Scientific reports · 2018Trial
- Ultrasound imaging of breast tumor perfusion and neovascular morphology.Ultrasound in medicine & biology · 2015Trial
- A phase II study of sagopilone (ZK 219477; ZK-EPO) in patients with breast cancer and brain metastases.Clinical breast cancer · 2011Trial
- Detecting vascular normalization in epithelial ovarian cancer.Medical oncology (Northwood, London, England) · 2025Review
- Vascular tortuosity is related to reduced thalamic volume after middle cerebral artery occlusion.Heliyon · 2023Article
- Novel Radiomic Measurements of Tumor-Associated Vasculature Morphology on Clinical Imaging as a Biomarker of Treatment Response in Multiple Cancers.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022Article
- Predicting cancer outcomes with radiomics and artificial intelligence in radiology.Nature reviews. Clinical oncology · 2022Review
- Urinary sodium and potassium excretion and cerebrovascular health: a multimodal imaging study.European journal of nutrition · 2021Article
- Relationship between 7T MR-angiography features of vascular injury and cognitive decline in young brain tumor patients treated with radiation therapy.Journal of neuro-oncology · 2021Article
- Glioblastoma multiforme restructures the topological connectivity of cerebrovascular networks.Scientific reports · 2019Article
- Targeting the vasculature of tumours: combining VEGF pathway inhibitors with radiotherapy.The British journal of radiology · 2019Review
- Non-invasive MR assessment of macroscopic and microscopic vascular abnormalities in the rectal tumour-surrounding mesorectum.European radiology · 2016Article
- Tumour angiogenesis as a chemo-mechanical surface instability.Scientific reports · 2016Article
- CNS metastases in breast cancer: old challenge, new frontiers.Clinical cancer research : an official journal of the American Association for Cancer Research · 2013Review
- Science and technology of the emerging nanomedicines in cancer therapy: A primer for physicians and pharmacists.SAGE open medicine · 2013Article
- Breast cancer brain metastases: new directions in systemic therapy.Ecancermedicalscience · 2013Article
- Multiscale imaging and computational modeling of blood flow in the tumor vasculature.Annals of biomedical engineering · 2012Review
- Vascular normalization as a therapeutic strategy for malignant and nonmalignant disease.Cold Spring Harbor perspectives in medicine · 2012Review
- Treatment of Breast Cancer Brain Metastases.Current breast cancer reports · 2012Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeTo prospectively determine if magnetic resonance (MR) angiography can depict intracranial vascular morphologic changes during treatment of brain metastases from breast cancer and if serial quantitative vessel tortuosity measurements can be used to predict tumor treatment response sooner than traditional methods. MATERIALS AND
methodsInstitutional review board approval and informed consent were obtained for this HIPAA-compliant study. Twenty-two women aged 31-61 years underwent brain MR angiography prior to and 2 months after initiation of lapatinib therapy for brain metastases from breast cancer. Vessels were extracted from MR angiograms with a computer program. Changes in vessel number, radius, and tortuosity were calculated mathematically, normalized with values obtained in 34 healthy control subjects (19 women, 15 men; age range, 19-72 years), and compared with subsequent assessments of tumor volume and clinical course.
resultsAll patients exhibited abnormal vessel tortuosity at baseline. Nineteen (86%) patients did not exhibit improvement in vessel tortuosity at 2-month follow-up, and all patients demonstrated tumor growth at 4-month follow-up. Vessel tortuosity measurements enabled us to correctly predict treatment failure 1-2 months earlier than did traditional methods. Three (14%) patients had quantitative improvement in vessel tortuosity at 2-month follow-up, with drop out of small abnormal vessels and straightening of large vessels. Each of the two patients for whom further follow-up data were available responded to treatment for more than 6 months.
conclusionStudy results established the feasibility of using MR angiography to quantify vessel shape changes during therapy. Although further research is required, results suggest that changes in vessel tortuosity might enable early prediction of tumor treatment response.
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