ArticleThe Journal of cell biology2007
Differences between homologous alleles of olfactory receptor genes require the Polycomb Group protein Eed.
Article in The Journal of cell biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- An epigenetic repressor TRIM66 dictates monogenic olfactory receptor expression, neural activity, and olfactory behavior.Nature communications · 2025Article
- Epigenetic control of chromosome-associated lncRNA genes essential for replication and stability.Nature communications · 2022Article
- Multi-omic profiling of histone variant H3.3 lysine 27 methylation reveals a distinct role from canonical H3 in stem cell differentiation.Molecular omics · 2022Article
- Asynchronous Replication Timing: A Mechanism for Monoallelic Choice During Development.Frontiers in cell and developmental biology · 2021Review
- Reciprocal monoallelic expression of ASAR lncRNA genes controls replication timing of human chromosome 6.RNA (New York, N.Y.) · 2020Article
- L1 retrotransposon antisense RNA within ASAR lncRNAs controls chromosome-wide replication timing.The Journal of cell biology · 2018Article
- ASAR15, A cis-acting locus that controls chromosome-wide replication timing and stability of human chromosome 15.PLoS genetics · 2015Article
- Nuclear compartmentalization of odorant receptor genes.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Smchd1 regulates a subset of autosomal genes subject to monoallelic expression in addition to being critical for X inactivation.Epigenetics & chromatin · 2013Article
- Importance of the matriline for genomic imprinting, brain development and behaviour.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- Article
- Genomic imprinting and epigenetic control of development.Cold Spring Harbor perspectives in biology · 2012Article
- Distinct distribution of ectopically expressed histone variants H2A.Bbd and MacroH2A in open and closed chromatin domains.PloS one · 2012Article
- Epigenetics of haematopoietic cell development.Nature reviews. Immunology · 2011Review
- Epigenetic control of recombination in the immune system.Seminars in immunology · 2010Review
- YY1's DNA-binding motifs in mammalian olfactory receptor genes.BMC genomics · 2009Article
- Endonuclease-sensitive regions of human spermatozoal chromatin are highly enriched in promoter and CTCF binding sequences.Genome research · 2009Article
- Monoallelic gene expression in mammals.Chromosoma · 2009Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
A number of mammalian genes are expressed from only one of the two homologous chromosomes, selected at random in each cell. These include genes subject to X-inactivation, olfactory receptor (OR) genes, and several classes of immune system genes. The means by which monoallelic expression is established are only beginning to be understood. Using a cytological assay, we show that the two homologous alleles of autosomal random monoallelic loci differ from each other in embryonic stem (ES) cells, before establishment of monoallelic expression. The Polycomb Group gene Eed is required to establish this distinctive behavior. In addition, we found that when Eed mutant ES cells are differentiated, they fail to establish asynchronous replication timing at OR loci. These results suggest a common mechanism for random monoallelic expression on autosomes and the X chromosome, and implicate Eed in establishing differences between homologous OR loci before and after differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.