Evidence map›Paper›PMID 17953769›Full record

ArticleGenome biology2007

A BAC clone fingerprinting approach to the detection of human genome rearrangements.

Martin Krzywinski, Ian Bosdet, Carrie Mathewson, Natasja Wye, Jay Brebner, Readman Chiu, Richard Corbett, Matthew Field, Darlene Lee, Trevor Pugh and 6 more

Abstract readComparative Study
In one paragraph

Article in Genome biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Smoking-related genomic signatures in non-small cell lung cancer.American journal of respiratory and critical care medicine · 2008
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Martin KrzywinskiBC Cancer Agency Genome Sciences Centre, West 7th Avenue, Vancouver, British Columbia, Canada V5Z 4S6. martink@bcgsc.ca
Ian Bosdet
Carrie Mathewson
Natasja Wye
Jay Brebner
Readman Chiu
Richard Corbett
Matthew Field
Darlene Lee
Trevor Pugh
Stas Volik
Asim Siddiqui
Steven Jones
Jacquie Schein
Collin Collins
Marco Marra

Funding

Improvements in BAC fingerprinting and end sequencingU01HG002743 · NHGRI · BRITISH COLUMBIA CANCER AGENCY · PI MARRA, MARCO A. · 2003 to 2005
$4.3M
NHGRI NIH HHS 5-U01-HG002743-03NHGRI NIH HHS U01 HG002743
6 · The paper itself

Abstract

We present a method, called fingerprint profiling (FPP), that uses restriction digest fingerprints of bacterial artificial chromosome clones to detect and classify rearrangements in the human genome. The approach uses alignment of experimental fingerprint patterns to in silico digests of the sequence assembly and is capable of detecting micro-deletions (1-5 kb) and balanced rearrangements. Our method has compelling potential for use as a whole-genome method for the identification and characterization of human genome rearrangements.

Indexed as

Chromosomes, Artificial, BacterialComputer SimulationDNA FingerprintingDNA PrimersDNA Restriction EnzymesGene RearrangementGenome, HumanHumansDNA PrimersDNA Restriction Enzymes

Identifiers

PMID17953769
PMCPMC2246298

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.