ArticleLa Radiologia medica2007
Bone metastases in breast cancer: higher prevalence of osteosclerotic lesions.
Article in La Radiologia medica, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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20 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Female sex is associated with a lower risk of bone metastases and favourable prognosis in non-sex-specific cancers.BMC cancer · 2019Pooled it
- Research progress of bone metastases: From disease recognition to clinical practice.Frontiers in oncology · 2022Review
- Temperature Monitoring in Hyperthermia Treatments of Bone Tumors: State-of-the-Art and Future Challenges.Sensors (Basel, Switzerland) · 2021Review
- Cross Talk Between Macrophages and Cancer Cells in the Bone Metastatic Environment.Frontiers in endocrinology · 2021Review
- Early response of bone metastases can predict tumor response in patients with non-small-cell lung cancer with bone metastases in the treatment with nivolumab.Oncology letters · 2020Article
- Bone metastases: a comprehensive review of the literature.Molecular biology reports · 2020Review
- Early osteosclerotic changes predict chemotherapy response in non-small-cell lung cancer patients with bone metastases.European radiology · 2018Article
- Extensive Re-ossification and Reformation of the Proximal Femur After External Beam Radiotherapy in Metastatic Carcinoma Breast.Indian journal of surgical oncology · 2018Article
- Effect of Bone Reading CT software on radiologist performance in detecting bone metastases from breast cancer.The British journal of radiology · 2017Article
- The Breast Cancer to Bone (B2B) Metastases Research Program: a multi-disciplinary investigation of bone metastases from breast cancer.BMC cancer · 2015Article
- VALIDATION OF THERAPEUTIC RESPONSE ASSESSMENT BY BONE SCINTIGRAPHY IN PATIENTS WITH BONE-ONLY METASTATIC BREAST CANCERS DURING ZOLEDRONIC ACID TREATMENT: COMPARISON WITH COMPUTED TOMOGRAPHY ASSESSMENT.Fukushima journal of medical science · 2015Article
- Differential effect of zoledronic acid on normal trabecular and cortical bone density in oncologic patients with bone metastases.Journal of bone oncology · 2012Article
- RANK, RANKL and OPG Expression in Breast Cancer - Influence on Osseous Metastasis.Geburtshilfe und Frauenheilkunde · 2012Article
- Radionuclide Therapy of Bone Metastases.Breast care (Basel, Switzerland) · 2012Article
- Radiological changes following second-line zoledronic acid treatment in breast cancer patients with bone metastases.Clinical & experimental metastasis · 2009Article
- Targeting angiogenesis-dependent calcified neoplasms using combined polymer therapeutics.PloS one · 2009Article
- Automated CT-based analysis to detect changes in the prevalence of lytic bone metastases from breast cancer.Clinical & experimental metastasis · 2009Article
- Types of bone metastases in women with breast cancer undergoing systemic treatments.La Radiologia medica · 2008Article
- A prospective analysis of CT density measurements of bone metastases after treatment with zoledronic acid.Skeletal radiology · 2007Article
- Metastatic adenocarcinoma of Proximal Femur treated by Custom made Hip Prosthesis.Journal of orthopaedic case reportsArticle
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8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIt is well known that bone metastases from breast cancer usually show osteolytic changes. We retrospectively analysed the computed tomography (CT) appearance of bone metastases to quantify the distribution of lytic, mixed and sclerotic changes in a series of patients presenting with neoplastic bone involvement from breast cancer. MATERIALS AND
methodsBetween 1996 and 2005, 468 women with a diagnosis of breast cancer were referred to our department for staging or follow-up CT examinations. Staging CT examinations detected systemic metastases in 142/468 patients, 60 of which had bone involvement. Patients with a second primary tumour or bone metabolic disorders were excluded from this retrospective analysis.
resultsIn patients with bone metastases, CT identified 18 with osteolytic lesions (30%), 32 with osteosclerotic lesions (53.3%) and ten with mixed lesions (16.7%). Analysis of the cases observed for the first time during the 1996-2000 period showed osteolytic lesions in 53.6% (15/28), osteosclerotic lesions in 32.1% (9/28) and mixed lesions in 14.3% (4/28). Results were 9.4% (3/32), 71.9% (23/32) and 18.7% (6/32), respectively, for the same groups in the 2001-2005 period. Histological analysis of all cases included 81.9% of infiltrative ductal carcinoma, 11.2% of infiltrative lobular carcinoma, 3.7% of ductal lobular mixed carcinoma and 3% of medullar carcinoma. We found no statistically significant correlation between histological type of breast cancer and radiological appearance of bone metastasis. A significant difference between patients treated with or without zoledronic acid was observed, with a higher prevalence of osteosclerotic lesions in the former group of patients (p<0.05).
conclusionsWe observed an increasing prevalence of osteosclerotic bone metastasis when comparing the 1996-2000 period with the 2001-2005 period. The significance of these distribution changes is not clear. However, we found a significant correlation of osteosclerotic lesions with zoledronic acid treatment. The advent of third generation bisphosphonates may have changed the CT appearance of bone metastasis from breast cancer.
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