ArticleJournal of molecular neuroscience : MN2007
Nicotine modulates the renin-angiotensin system of cultured neurons and glial cells from cardiovascular brain areas of Wistar Kyoto and spontaneously hypertensive rats.
Article in Journal of molecular neuroscience : MN, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 39 citations in OpenAlex.
- Association between the urine tobacco metabolite levels and physical health in Chinese primary school students with secondhand smoke exposure.Frontiers in public health · 2025Article
- Structural Features Influencing the Bioactive Conformation of Angiotensin II and Angiotensin A: Relationship between Receptor Desensitization, Addiction, and the Blood-Brain Barrier.International journal of molecular sciences · 2024Review
- The double-edged nature of nicotine: toxicities and therapeutic potentials.Frontiers in pharmacology · 2024Review
- Associations of active and passive tobacco exposure with elevated blood pressure in Korean adolescents.Epidemiology and health · 2024Article
- Effect of heated tobacco products and traditional cigarettes on pulmonary toxicity and SARS-CoV-2-induced lung injury.Toxicology · 2022Article
- Review
- Paradoxical effects of cigarette smoke and COPD on SARS-CoV-2 infection and disease.BMC pulmonary medicine · 2021Article
- How Does COVID-19 Affect the Neurobiology of Suicide?Current psychiatry reports · 2021Review
- Severe acute respiratory syndrome coronavirus 2 infection reaches the human nervous system: How?Journal of neuroscience research · 2021Review
- The Role of Smoking and Nicotine in the Transmission and Pathogenesis of COVID-19.The Journal of pharmacology and experimental therapeutics · 2020Review
- Implications for Neuromodulation Therapy to Control Inflammation and Related Organ Dysfunction in COVID-19.Journal of cardiovascular translational research · 2020Review
- COVID-19 and the central nervous system.Clinical neurology and neurosurgery · 2020Review
- Mas receptor is translocated to the nucleus upon agonist stimulation in brainstem neurons from spontaneously hypertensive rats but not normotensive rats.Cardiovascular research · 2020Article
- Is nicotine exposure linked to cardiopulmonary vulnerability to COVID-19 in the general population?The FEBS journal · 2020Review
- The role of the exposome in promoting resilience or susceptibility after SARS-CoV-2 infection.Journal of exposure science & environmental epidemiology · 2020Article
- Altered COVID-19 receptor ACE2 expression in a higher risk group for cerebrovascular disease and ischemic stroke.Biochemical and biophysical research communications · 2020Article
- Cigarette Smoke Exposure and Inflammatory Signaling Increase the Expression of the SARS-CoV-2 Receptor ACE2 in the Respiratory Tract.Developmental cell · 2020Article
- Does COVID19 Infect the Brain? If So, Smokers Might Be at a Higher Risk.Molecular pharmacology · 2020Article
- COVID-19, COPD, and AECOPD: Immunological, Epidemiological, and Clinical Aspects.Frontiers in medicine · 2020Review
- Nicotine and the renin-angiotensin system.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Considering the importance of the renin-angiotensin system (RAS) for the central control of blood pressure and that nicotine increases the probability of development of hypertension associated to genetic predisposition, our aims are (1) to determine RAS in cultured neurons and glia from the brainstem and hypothalamus of spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) rats; (2) to analyze the possibility of nicotine to interact with brain RAS; and (3) to hypothesize any contribution of nicotine and RAS to the development of neurogenic hypertension. This study demonstrated physiological differences in RAS between cultured neuronal and glial cells from the brainstem and hypothalamus of SHR and WKY neonate rats. Our study also featured evidences of direct modulation of the RAS by nicotine in neurons and glia of brainstem and hypothalamus, which seems to be differential between the two rat strains. Such modulation gives us a clue about the mechanisms possibly involved in the genesis of neurogenic hypertension in vivo, for example, increase in angiotensin II type 1 receptor binding and decrease in angiotensin-converting enzyme 2. In conclusion, we demonstrated that neuronal and glial RAS from the brainstem and hypothalamus of SHR differ from WKY rats and nicotine differentially modulates the brain RAS in SHR and WKY.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.