ArticleJournal of materials science. Materials in medicine2008
Stealth dendrimers for drug delivery: correlation between PEGylation, cytocompatibility, and drug payload.
Article in Journal of materials science. Materials in medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Ultrasonic-assisted enzymatic extraction ofRSC advances · 2020Article
- Polyphosphazene polymers: The next generation of biomaterials for regenerative engineering and therapeutic drug delivery.Journal of vacuum science and technology. B, Nanotechnology & microelectronics : materials, processing, measurement, & phenomena : JVST B · 2020Review
- Partial Surface Modification of Low Generation Polyamidoamine Dendrimers: Gaining Insight into their Potential for Improved Carboplatin Delivery.Biomolecules · 2019Article
- Modified Carboxyl-Terminated PAMAM Dendrimers as Great Cytocompatible Nano-Based Drug Delivery System.International journal of molecular sciences · 2019Article
- Polyamidoamine Dendrimer Microgels: Hierarchical Arrangement of Dendrimers into Micrometer Domains with Expanded Structural Features for Programmable Drug Delivery and Release.Macromolecules · 2018Article
- A pH-sensitive Macromolecular Prodrug as TLR7/8 Targeting Immune Response Modifier.Chemistry (Weinheim an der Bergstrasse, Germany) · 2017Article
- Bolstering cholesteryl ester hydrolysis in liver: A hepatocyte-targeting gene delivery strategy for potential alleviation of atherosclerosis.Biomaterials · 2017Article
- Inhibition of Murine Norovirus and Feline Calicivirus by Edible Herbal Extracts.Food and environmental virology · 2017Article
- Oxidative damage induced by copper in mouse primary hepatocytes by single-cell analysis.Environmental science and pollution research international · 2016Article
- Electrospinning of PEGylated polyamidoamine dendrimer fibers.Materials science & engineering. C, Materials for biological applications · 2015Article
- Click hybridization of immune cells and polyamidoamine dendrimers.Advanced healthcare materials · 2014Article
- Zwitterionic chitosan-polyamidoamine dendrimer complex nanoparticles as a pH-sensitive drug carrier.Molecular pharmaceutics · 2013Article
- Dendrimer nanoscaffolds for potential theranostics of prostate cancer with a focus on radiochemistry.Molecular pharmaceutics · 2013Review
- Polyphosphazenes: Multifunctional, Biodegradable Vehicles for Drug and Gene Delivery.Polymers · 2013Article
- Poly (ethylene glycol)-armed hyperbranched polyoxetanes for anticancer drug delivery.Journal of bioactive and compatible polymers · 2012Article
- Intrinsic dynamics of DNA-polymer complexes: a mechanism for DNA release.Molecular pharmaceutics · 2012Article
- Peptide- and saccharide-conjugated dendrimers for targeted drug delivery: a concise review.Interface focus · 2012Article
- Designing dendrimers for drug delivery and imaging: pharmacokinetic considerations.Pharmaceutical research · 2011Review
- Function of mesenchymal stem cells following loading of gold nanotracers.International journal of nanomedicine · 2011Article
- Nanoparticle-mediated brain-specific drug delivery, imaging, and diagnosis.Pharmaceutical research · 2010Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is advantageous to utilize low generation polyamidoamine (PAMAM) dendrimers for drug delivery because low generations (generation 4.0 or below) have more biologically favorable properties as compared to high generations. Nevertheless, modification of low generation dendrimers with PEG to create stealth dendrimers is still necessary to avoid potential side effects by long term accumulation. However, low generation dendrimers have much fewer surface sites for drug loading as compared to higher generations. To efficiently utilize low generation dendrimer-based stealth dendrimers for drug loading, PEGylation needs to be optimized. In this study, we synthesized a series of stealth dendrimers based on low generation Starburst PAMAM dendrimers (i.e., G2.5, G3.0, G3.5, and G4.0) and quantitatively assessed PEGylation efficacy in modulating cytocompatibility of low generation PAMAM dendrimers. Cytocompatibility of stealth dendrimers was examined using endothelial cells. The results showed that PEGylation degree on low generation dendrimers could be dramatically reduced to leave as many unoccupied surface groups as possible for drug loading, while maintaining the drug carrier cytocompatibility. 3PEGs-G3.0 and 10PEGs-G4.0 were considered initially optimized stealth dendrimers that would be further modified to deliver drugs of interest. Correlation of PEGylation, cytocompatibility, and drug payload allowed us to optimize low generation dendrimer-based stealth dendrimers for drug delivery and advance the understanding of structure-property relationship of stealth dendrimers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.