ArticleJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology2008
High-definition spatiotemporal mapping of contractile activity in the isolated proximal colon of the rabbit.
Article in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 64 citations in OpenAlex.
- Rheology of human faeces and pathophysiology of defaecation.Techniques in coloproctology · 2020Article
- Relationships Between Distention-, Butyrate- and Pellet-Induced Stimulation of Peristalsis in the Mouse Colon.Frontiers in physiology · 2020Article
- First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques.Nature reviews. Gastroenterology & hepatology · 2019Review
- Recent advances in intestinal smooth muscle research: from muscle strips and single cells, via ICC networks to whole organ physiology and assessment of human gut motor dysfunction.Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2019Article
- Image velocimetry and spectral analysis enable quantitative characterization of larval zebrafish gut motility.Neurogastroenterology and motility · 2018Article
- Predicting the viscosity of digesta from the physical characteristics of particle suspensions using existing rheological models.Journal of the Royal Society, Interface · 2018Article
- Quantifying Patterns of Smooth Muscle Motility in the Gut and Other Organs With New Techniques of Video Spatiotemporal Mapping.Frontiers in physiology · 2018Article
- Characterization of Simultaneous Pressure Waves as Biomarkers for Colonic Motility Assessed by High-Resolution Colonic Manometry.Frontiers in physiology · 2018Article
- Intraluminal pressure patterns in the human colon assessed by high-resolution manometry.Scientific reports · 2017Article
- Relationships between motor patterns and intraluminal pressure in the 3-taeniated proximal colon of the rabbit.Scientific reports · 2017Article
- Spatiotemporal Mapping Techniques Show Clozapine Impairs Neurogenic and Myogenic Patterns of Activity in the Colon of the Rabbit in a Dose-Dependent Manner.Frontiers in pharmacology · 2017Article
- Insights into the mechanisms underlying colonic motor patterns.The Journal of physiology · 2016Review
- Ex vivo motility in the base of the rabbit caecum and its associated structures: an electrophysiological and spatiotemporal analysis.Journal of physiology and biochemistry · 2016Article
- A review of mixing and propulsion of chyme in the small intestine: fresh insights from new methods.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2015Review
- Quantification of in vivo colonic motor patterns in healthy humans before and after a meal revealed by high-resolution fiber-optic manometry.Neurogastroenterology and motility · 2014Article
- Interstitial cells of Cajal: update on basic and clinical science.Current gastroenterology reports · 2014Review
- Effects of hydrogen sulphide on motility patterns in the rat colon.British journal of pharmacology · 2013Article
- An experimental method to identify neurogenic and myogenic active mechanical states of intestinal motility.Frontiers in systems neuroscience · 2013Article
- Neurogenic and myogenic properties of pan-colonic motor patterns and their spatiotemporal organization in rats.PloS one · 2013Article
- Spatiotemporal mapping of ex vivo motility in the caecum of the rabbit.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Four types of contractile activity were identified and characterised in the isolated triple haustrated proximal colon of the rabbit using high-definition spatiotemporal mapping techniques. Mass peristalses were hexamethonium-sensitive deep circular contractions with associated taenial longitudinal contractile activity that occurred irregularly and propagated rapidly aborad, preceded by a zone of local lumen distension. They were sufficiently sustained for each event to occupy the length of the isolated colonic segment and the contraction persisted longer orally than aborally, the difference being more pronounced when lumen contents were viscous. Haustra were bounded by deep even-spaced ring contractions that progressed slowly aborad (haustral progression). Haustral formation and progression were hexamethonium-sensitive and coordinated across intertaenial domains. Ripples were hexamethonium-resistant phasic circular contractions that propagated predominantly orad at varying rates. In the presence of haustra, they were uncoordinated across intertaenial domains but were more coordinated when haustra were absent. Fast phasic contractions were relatively shallow hexamethonium-resistant contractions that propagated rapidly in a predominantly aborad direction. Fast phasic circular contractions were accompanied by taenial longitudinal muscle contractions which increased in amplitude prior to a mass peristaltic event and following the administration of hexamethonium. On the basis of the concurrence and interaction of these contractile activities, we hypothesise that dual pacemakers are present with fast phasic contractions being modulated by the interstitial cells of Cajal in the Auerbach's plexus (ICC-MY) while ripples are due to the submucosal ICC (ICC-SM). Further, that ICC-SM mediate the enteric motor neurons that generate haustral progression, while the intramuscular ICC (ICC-IM) mediate mass peristalsis. The orad movement of watery fluid was possibly due to ripples in the absence of haustra.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.