ReviewArchives of disease in childhood. Fetal and neonatal edition2007
Patent ductus arteriosus: lack of evidence for common treatments.
Review in Archives of disease in childhood. Fetal and neonatal edition, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
79 citing papers in PubMed, 5 syntheses or guidelines pooled it, 198 citations in OpenAlex.
- Targeted Neonatal Echocardiography in Neonatal Patent Ductus Arteriosus Management: A Systematic Review of Clinical Utility and Outcomes.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Beneficial vs harmful effects of pharmacological treatment of patent ductus arteriosus: A Bayesian meta-analysis.Pediatric research · 2025Pooled it
- Factors Associated With Benefit of Treatment of Patent Ductus Arteriosus in Preterm Infants: A Systematic Review and Meta-Analysis.Frontiers in pediatrics · 2021Pooled it
- Chest shielding for prevention of a haemodynamically significant patent ductus arteriosus in preterm infants receiving phototherapy.The Cochrane database of systematic reviews · 2015Pooled it
- Patent ductus arteriosus in preterm neonates.Indian journal of pediatrics · 2008Guideline
- Artificial intelligence model comparison for risk factor analysis of patent ductus arteriosus in nationwide very low birth weight infants cohort.Scientific reports · 2021Trial
- Serial echocardiography in very preterm infants: a pilot randomized trial.Acta paediatrica (Oslo, Norway : 1992) · 2013Trial
- Improved closure of patent ductus arteriosus with high doses of ibuprofen.Pediatric cardiology · 2012Trial
- Association of low shunt burden from PDA and adverse outcomes in premature infants.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Risk factors of acute kidney injury in extremely low gestational age neonates (ELGANs) - a retrospective case-control study.Pediatric nephrology (Berlin, Germany) · 2025Article
- At a crossroads for early medical treatment of persistent patent ductus arteriosus in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2024Review
- Factors Predicting Spontaneous Closure of Patent Ductus Arteriosus in Very Low Birth Weight Neonates.Cureus · 2024Article
- Narrative Review on Echocardiographic Evaluation of Patent Ductus Arteriosus in Preterm Infants.Journal of cardiovascular development and disease · 2024Review
- Targeted neonatal echocardiography for patent ductus arteriosus in neonates reduces the surgical ligation rate without affecting healthcare outcomes.Translational pediatrics · 2023Article
- Feasibility, Safety, and Short-Term Outcomes of Transcatheter Patent Ductus Arteriosus Closure in Premature Infants on High-Frequency Jet Ventilation.Journal of the American Heart Association · 2022Article
- Transcatheter Occlusion of a Patent Ductus Arteriosus for a Symptomatic Left-to-Right Shunt.Cureus · 2022Article
- Impact of Medical Treatment of Hemodynamically Significant Patent Ductus Arteriosus on Cerebral and Renal Tissue Oxygenation Measured by Near-Infrared Spectroscopy in Very Low-Birth-Weight Infants.Medicina (Kaunas, Lithuania) · 2022Article
- Covariation of changing patent ductus arteriosus management and preterm infant outcomes in Pediatrix neonatal intensive care units.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- Patent ductus arteriosus treatment trends and associated morbidities in neonates.Scientific reports · 2021Article
- Early Role of the Atrial-Level Communication in Premature Infants with Patent Ductus Arteriosus.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2021Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
- Commented on by
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patent ductus arteriosus (PDA) is a common diagnosis among extremely premature infants, especially in those with lung disease. Treatments are often used to close the PDA. Despite nearly three decades of research, the question of whether the benefits of treatments to prevent ductal patency or promote closure outweigh the risks of these treatments remains unanswered. The authors rarely use treatments designed to close the PDA. This article reviews three considerations in support of this restrained approach: rates of spontaneous closure of the ductus arteriosus; adverse effect of persistent ductal patency; and benefits and risks of treatments for closure.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.