ArticleEukaryotic cell2008
Mat formation in Saccharomyces cerevisiae requires nutrient and pH gradients.
Article in Eukaryotic cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 62 citations in OpenAlex.
- The role ofmBio · 2026Article
- Acute high shear stress enhances fungal cell/substrate adhesion.Microbiology spectrum · 2026Article
- The Saccharomyces cerevisiae ∑1278b strain is sensitive to NaCl because of mutations in its ENA1 gene.FEMS yeast research · 2025Article
- KtrB-mediated alkaline adaptation drivesFrontiers in microbiology · 2025Article
- Variation in pH gradients and FLO11 expression in mat biofilms from environmental isolates of the yeast Saccharomyces cerevisiae.MicrobiologyOpen · 2022Article
- Gene by Environment Interactions reveal new regulatory aspects of signaling network plasticity.PLoS genetics · 2022Article
- FLO11, a Developmental Gene Conferring Impressive Adaptive Plasticity to the YeastPathogens (Basel, Switzerland) · 2021Review
- The Flo Adhesin Family.Pathogens (Basel, Switzerland) · 2021Review
- Variation at an adhesin locus suggests sociality in natural populations of the yeastProceedings. Biological sciences · 2019Article
- Going with the Flo: The Role of Flo11-Dependent and Independent Interactions in Yeast Mat Formation.Journal of fungi (Basel, Switzerland) · 2018Review
- Adhesins of Yeasts: Protein Structure and Interactions.Journal of fungi (Basel, Switzerland) · 2018Review
- Bioelectronics communication: encoding yeast regulatory responses using nanostructured gallium nitride thin films.Nanoscale · 2018Article
- Nutrient depletion modifies cell wall adsorption activity of wine yeast.World journal of microbiology & biotechnology · 2016Article
- Fumarate Production by Torulopsis glabrata: Engineering Heterologous Fumarase Expression and Improving Acid Tolerance.PloS one · 2016Article
- Biofilm/Mat assays for budding yeast.Cold Spring Harbor protocols · 2015Article
- Two-dimensionality of yeast colony expansion accompanied by pattern formation.PLoS computational biology · 2014Article
- Methodologies to generate, extract, purify and fractionate yeast ECM for analytical use in proteomics and glycomics.BMC microbiology · 2014Article
- The Wsc1p cell wall signaling protein controls biofilm (Mat) formation independently of Flo11p in Saccharomyces cerevisiae.G3 (Bethesda, Md.) · 2014Article
- RACK1/Asc1p, a ribosomal node in cellular signaling.Molecular & cellular proteomics : MCP · 2013Article
- Identification of a complex genetic network underlying Saccharomyces cerevisiae colony morphology.Molecular microbiology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The ability of Saccharomyces cerevisiae to form morphologically complex colony-like structures called mats requires expression of the cell surface glycoprotein Flo11p and growth on a semisolid surface. As the mat grows, it forms two visually distinct populations called the rim (edge of the mat) and the hub (interior of the mat), which can be physically separated from one another based on their agar adherence properties. Here, we show that growth of the mat on a semisolid agar surface creates concentric glucose and pH gradients in the medium that are required for the differentiation of the hub and rim. Disruption of the pathways that respond to changing levels of glucose block mat formation by decreasing FLO11 expression. However, in wild-type cells, Flo11p is expressed in both portions of the structure. The difference in adherence between the rim and hub appears to be a consequence of the reduced adherence of Flo11p at the elevated pH of the rim.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.