ArticleEukaryotic cell2007
Spatial differentiation in the vegetative mycelium of Aspergillus niger.
Article in Eukaryotic cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 127 citations in OpenAlex.
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- A Nuclei-Based Conceptual Model of (Eco)evolutionary Dynamics in Fungal Heterokaryons.Frontiers in microbiology · 2022Article
- The Cultivation Method Affects the Transcriptomic Response of Aspergillus niger to Growth on Sugar Beet Pulp.Microbiology spectrum · 2021Article
- Unconventional Secretion of Nigerolysins A fromMicroorganisms · 2020Article
- Syncytia in Fungi.Cells · 2020Review
- Colonies of the fungus Aspergillus niger are highly differentiated to adapt to local carbon source variation.Environmental microbiology · 2020Article
- Absence of AfuXpot, the yeast Los1 homologue, limits Aspergillus fumigatus growth under amino acid deprived condition.World journal of microbiology & biotechnology · 2020Article
- Aspergillus fumigatus and Aspergillosis in 2019.Clinical microbiology reviews · 2019Review
- Efficient marker free CRISPR/Cas9 genome editing for functional analysis of gene families in filamentous fungi.Fungal biology and biotechnology · 2019Article
- The Early Asexual Development RegulatorFrontiers in microbiology · 2019Article
- Autolytic hydrolases affect sexual and asexual development of Aspergillus nidulans.Folia microbiologica · 2018Article
- How a fungus shapes biotechnology: 100 years ofFungal biology and biotechnology · 2018Review
- Functional distinction of hyphal compartments.Scientific reports · 2017Article
- Cell Biology of Hyphal Growth.Microbiology spectrum · 2017Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fungal mycelia are exposed to heterogenic substrates. The substrate in the central part of the colony has been (partly) degraded, whereas it is still unexplored at the periphery of the mycelium. We here assessed whether substrate heterogeneity is a main determinant of spatial gene expression in colonies of Aspergillus niger. This question was addressed by analyzing whole-genome gene expression in five concentric zones of 7-day-old maltose- and xylose-grown colonies. Expression profiles at the periphery and the center were clearly different. More than 25% of the active genes showed twofold differences in expression between the inner and outermost zones of the colony. Moreover, 9% of the genes were expressed in only one of the five concentric zones, showing that a considerable part of the genome is active in a restricted part of the colony only. Statistical analysis of expression profiles of colonies that had either been or not been transferred to fresh xylose-containing medium showed that differential expression in a colony is due to the heterogeneity of the medium (e.g., genes involved in secretion, genes encoding proteases, and genes involved in xylose metabolism) as well as to medium-independent mechanisms (e.g., genes involved in nitrate metabolism and genes involved in cell wall synthesis and modification). Thus, we conclude that the mycelia of 7-day-old colonies of A. niger are highly differentiated. This conclusion is also indicated by the fact that distinct zones of the colony grow and secrete proteins, even after transfer to fresh medium.
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