ArticleApplied and environmental microbiology2007
CpxRA regulates mutualism and pathogenesis in Xenorhabdus nematophila.
Article in Applied and environmental microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- ThemBio · 2026Article
- CpxR and LrhA coordinate the regulation of Xenocoumacin 1 biosynthesis, flagellar assembly, and chemotaxis inFrontiers in microbiology · 2026Article
- Regulatory role of the Cpx ESR in bacterial behaviours.Virulence · 2024Review
- TheApplied and environmental microbiology · 2024Article
- OxyR is required for oxidative stress resistance of the entomopathogenic bacteriumMicrobiology (Reading, England) · 2024Article
- Cpx-signalling innpj antimicrobials and resistance · 2024Article
- A Skeptic's Guide to Bacterial Mechanosensing.Journal of molecular biology · 2020Review
- Molecular Regulators of Entomopathogenic Nematode-Bacterial Symbiosis.Results and problems in cell differentiation · 2020Review
- The CpxR regulates type VI secretion system 2 expression and facilitates the interbacterial competition activity and virulence of avian pathogenic Escherichia coli.Veterinary research · 2019Article
- Effects of cpxR on the growth characteristics and antibiotic production of Xenorhabdus nematophila.Microbial biotechnology · 2019Article
- CpxR negatively regulates the production of xenocoumacin 1, a dihydroisocoumarin derivative produced by Xenorhabdus nematophila.MicrobiologyOpen · 2019Article
- Regulation of antimicrobial activity and xenocoumacins biosynthesis by pH in Xenorhabdus nematophila.Microbial cell factories · 2017Article
- Nematode-bacteria mutualism: Selection within the mutualism supersedes selection outside of the mutualism.Evolution; international journal of organic evolution · 2016Article
- The Two-Component System CpxRA Negatively Regulates the Locus of Enterocyte Effacement of Enterohemorrhagic Escherichia coli Involving σ(32) and Lon protease.Frontiers in cellular and infection microbiology · 2016Article
- Comparison of Xenorhabdus bovienii bacterial strain genomes reveals diversity in symbiotic functions.BMC genomics · 2015Article
- The CpxRA two-component system is essential for Citrobacter rodentium virulence.Infection and immunity · 2015Article
- Dysregulation of Escherichia coli α-hemolysin expression alters the course of acute and persistent urinary tract infection.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Attenuated virulence and genomic reductive evolution in the entomopathogenic bacterial symbiont species, Xenorhabdus poinarii.Genome biology and evolution · 2014Article
- Escherichia coli isolate for studying colonization of the mouse intestine and its application to two-component signaling knockouts.Journal of bacteriology · 2014Article
- The Cpx stress response system potentiates the fitness and virulence of uropathogenic Escherichia coli.Infection and immunity · 2013Article
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Authors and funding
3 authors.
Funding
Abstract
The CpxRA signal transduction system, which in Escherichia coli regulates surface structure assembly and envelope maintenance, is involved in the pathogenic and mutualistic interactions of the entomopathogenic bacterium Xenorhabdus nematophila. When DeltacpxR1 cells were injected into Manduca sexta insects, the time required to kill 50% of the insects was twofold longer than the time observed for wild-type cells and the DeltacpxR1 cells ultimately killed 16% fewer insects than wild-type cells killed. During mutualistic colonization of Steinernema carpocapsae nematodes, the DeltacpxR1 mutant achieved colonization levels that were only 38% of the wild-type levels. DeltacpxR1 cells exhibited an extended lag phase when they were grown in liquid LB or hemolymph, formed irregular colonies on solid medium, and had a filamentous cell morphology. A mutant with a cpxRp-lacZ fusion had peaks of expression in the log and stationary phases that were conversely influenced by CpxR; the DeltacpxR1 mutant produced 130 and 17% of the wild-type beta-galactosidase activity in the log and stationary phases, respectively. CpxR positively influences motility and secreted lipase activity, as well as transcription of genes necessary for mutualistic colonization of nematodes. CpxR negatively influences the production of secreted hemolysin, protease, and antibiotic activities, as well as the expression of mrxA, encoding the pilin subunit. Thus, X. nematophila CpxRA controls expression of envelope-localized and secreted products, and its activity is necessary for both mutualistic and pathogenic functions.
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