ArticleProceedings of the National Academy of Sciences of the United States of America2007
Switchable DNA interfaces for the highly sensitive detection of label-free DNA targets.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Continuous monitoring of blood-interstitial fluid intercompartmental molecular kinetics in freely moving animals.Science advances · 2026Article
- Measuring Oligovalent Peptide-Virus Interactions Using Electrically Controllable DNA Nanostructures.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Nanomechanoelectrical approach to highly sensitive and specific label-free DNA detection.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Characterization of binding interactions of SARS-CoV-2 spike protein and DNA-peptide nanostructures.Scientific reports · 2022Article
- Electrochemical Beacon Method to Quantify 10 Attomolar Nucleic Acids with a Semilog Dynamic Range of 7 Orders of Magnitude.Analytical chemistry · 2021Article
- Ferrocene-Containing DNA Monolayers: Influence of Electrostatics on the Electron Transfer Dynamics.Langmuir : the ACS journal of surfaces and colloids · 2021Article
- Detection of CRISPR-dCas9 on DNA with Solid-State Nanopores.Nano letters · 2018Article
- Direct electrical control of IgG conformation and functional activity at surfaces.Scientific reports · 2016Article
- Electrical Stimulus Controlled Binding/Unbinding of Human Thrombin-Aptamer Complex.Scientific reports · 2016Article
- Electronic control of DNA-based nanoswitches and nanodevices.Chemical science · 2016Article
- Designing new strategy for controlling DNA orientation in biosensors.Scientific reports · 2015Article
- Electrically-driven modulation of surface-grafted RGD peptides for manipulation of cell adhesion.Chemical communications (Cambridge, England) · 2014Article
- Switching specific biomolecular interactions on surfaces under complex biological conditions.The Analyst · 2014Article
- Direct Observation of Reversible Biomolecule Switching Controlled By Electrical Stimulus.Advanced materials interfaces · 2014Article
- Modulation of Biointeractions by Electrically Switchable Oligopeptide Surfaces: Structural Requirements and Mechanism.Advanced materials interfaces · 2014Article
- BIOPHYSICAL PROPERTIES OF NUCLEIC ACIDS AT SURFACES RELEVANT TO MICROARRAY PERFORMANCE.Biomaterials science · 2014Article
- Label-free quantification of microRNAs using ligase-assisted sandwich hybridization on a DNA microarray.PloS one · 2014Article
- Sorting short fragments of single-stranded DNA with an evolving electric double layer.The journal of physical chemistry. B · 2013Article
- Label-free potentiometry for detecting DNA hybridization using peptide nucleic acid and DNA probes.Sensors (Basel, Switzerland) · 2013Article
- Protein analysis by time-resolved measurements with an electro-switchable DNA chip.Nature communications · 2013Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report a method to detect label-free oligonucleotide targets. The conformation of surface-tethered probe nucleic acids is modulated by alternating electric fields, which cause the molecules to extend away from or fold onto the biased surface. Binding (hybridization) of targets to the single-stranded probes results in a pronounced enhancement of the layer-height modulation amplitude, monitored optically in real time. The method features an exceptional detection limit of <3 x 10(8) bound targets per cm(2) sensor area. Single base-pair mismatches in the sequences of DNA complements may readily be identified; moreover, binding kinetics and binding affinities can be determined with high accuracy. When driving the DNA to oscillate at frequencies in the kHz regime, distinct switching kinetics are revealed for single- and double-stranded DNA. Molecular dynamics are used to identify the binding state of molecules according to their characteristic kinetic fingerprints by using a chip-compatible detection format.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.