ArticleJournal of bacteriology2007
Streptomyces coelicolor genes ftsL and divIC play a role in cell division but are dispensable for colony formation.
Article in Journal of bacteriology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Repression of mab_1999 impairs growth and alters cellular morphology of Mycobacterium abscessus.BMC microbiology · 2025Article
- FtsZ phosphorylation pleiotropically affects Z-ladder formation, antibiotic production, and morphogenesis in Streptomyces coelicolor.Antonie van Leeuwenhoek · 2023Article
- An Alternative and Conserved Cell Wall Enzyme That Can Substitute for the Lipid II Synthase MurG.mBio · 2021Article
- Influence of core divisome proteins on cell division inMicrobiology (Reading, England) · 2021Article
- Structural, Metabolic and Evolutionary Comparison of Bacterial Endospore and Exospore Formation.Frontiers in microbiology · 2021Review
- Visual and Microscopic Evaluation of Streptomyces Developmental Mutants.Journal of visualized experiments : JoVE · 2018Article
- Intra-species Genomic and Physiological Variability Impact Stress Resistance in Strains of Probiotic Potential.Frontiers in microbiology · 2018Article
- Taxonomy, Physiology, and Natural Products of Actinobacteria.Microbiology and molecular biology reviews : MMBR · 2016Review
- Developmental biology of Streptomyces from the perspective of 100 actinobacterial genome sequences.FEMS microbiology reviews · 2014Review
- Cytochrome P450 107U1 is required for sporulation and antibiotic production in Streptomyces coelicolor.Archives of biochemistry and biophysics · 2013Article
- Assembly of the Caulobacter cell division machine.Molecular microbiology · 2011Article
- LAB-Secretome: a genome-scale comparative analysis of the predicted extracellular and surface-associated proteins of Lactic Acid Bacteria.BMC genomics · 2010Article
- Multiple interaction domains in FtsL, a protein component of the widely conserved bacterial FtsLBQ cell division complex.Journal of bacteriology · 2010Article
- Streptomyces morphogenetics: dissecting differentiation in a filamentous bacterium.Nature reviews. Microbiology · 2009Review
- Medium-dependent phenotypes of Streptomyces coelicolor with mutations in ftsI or ftsW.Journal of bacteriology · 2009Article
- FtsW is a dispensable cell division protein required for Z-ring stabilization during sporulation septation in Streptomyces coelicolor.Journal of bacteriology · 2008Article
Corrections and comments
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3 authors.
Funding
Abstract
We have characterized homologues of the bacterial cell division genes ftsL and divIC in the gram-positive mycelial bacterium Streptomyces coelicolor A3(2). We show by deletion-insertion mutations that ftsL and divIC are dispensable for growth and viability in S. coelicolor. When mutant strains were grown on a conventional rich medium (R2YE, containing high sucrose), inactivation of either ftsL or divIC resulted in the formation of aerial hyphae with partially constricted division sites but no clear separation of prespore compartments. Surprisingly, this phenotype was largely suppressed when strains were grown on minimal medium or sucrose-free R2YE, where division sites in many aerial hyphae had finished constricting and chains of spores were evident. Thus, osmolarity appears to affect the severity of the division defect. Furthermore, double mutant strains deleted for both ftsL and divIC are viable and have medium-dependent phenotypes similar to that of the single mutant strains, suggesting that functions performed by FtsL and DivIC are not absolutely required for septation during growth and sporulation. Alternatively, another division protein may partially compensate for the loss of both FtsL and DivIC on minimal medium or sucrose-free R2YE. Finally, based on transmission electron microscopy observations, we propose that FtsL and DivIC are involved in coordinating symmetrical annular ingrowth of the invaginating septum.
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