Evidence map›Paper›PMID 17951389›Full record

ArticleJournal of bacteriology2007

Genetic diversity of the gene cluster encoding longus, a type IV pilus of enterotoxigenic Escherichia coli.

Oscar G Gomez-Duarte, Sujay Chattopadhyay, Scott J Weissman, Jorge A Giron, James B Kaper, Evgeni V Sokurenko

Abstract read
In one paragraph

Article in Journal of bacteriology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. RecombinantPathogens (Basel, Switzerland) · 2023
    Article
  3. Article
  4. Interplay of a secreted protein with type IVb pilus for efficient enterotoxigenicProceedings of the National Academy of Sciences of the United States of America · 2018
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Oscar G Gomez-DuarteDivision of Pediatric Infectious Diseases, University of Iowa Children's Hospital, 200 Hawkins Drive, Iowa City, IA 52242, USA. oscar-gomez@uiowa.edu
Sujay Chattopadhyay
Scott J Weissman
Jorge A Giron
James B Kaper
Evgeni V Sokurenko

Funding

Molecular Genetics of Enteropathogenic E. Coli AdhesionR37AI021657 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI KAPER, JAMES B · 2004 to 2013
$4.8M
NOVEL E. COLI 0157:H7 INTESTINAL COLONIZATION FACTORSR01DK058957 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI KAPER, JAMES B · 2000 to 2009
$3.1M
AN EVOLUTIONARY ANALYSIS OF FIMBRIAE IN ENTEROBACTERIAR01GM060731 · NIGMS · UNIVERSITY OF LOUISVILLE · PI DYKHUIZEN, DANIEL E. · 2000 to 2007
$2.6M
MOLECULAR GENETICS OF ENTEROPATHOGENIC E COLI ADHESIONR01AI021657 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI KAPER, JAMES B · 1989 to 2003
$1.4M
MOLECULAR GENETICS OF ENTEROPATHOGENIC E. COLI ADHESIONR22AI021657 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI KAPER, JAMES B · 1986 to 1991
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NIAID NIH HHS AI21657NIAID NIH HHS R01 AI021657NIAID NIH HHS R37 AI021657NIDDK NIH HHS DK58957NIDDK NIH HHS R01 DK058957NIGMS NIH HHS GM60731NIGMS NIH HHS R01 GM060731
6 · The paper itself

Abstract

Enterotoxigenic Escherichia coli (ETEC) strains produce a type IV pilus named Longus. We identified a 16-gene cluster involved in the biosynthesis of Longus that has 57 to 95% identity at the protein level to CFA/III, another type IV pilus of ETEC. Alleles of the Longus structural subunit gene lngA demonstrate a diversity of 12 to 19% at the protein level with strong positive selection for point replacements and horizontal transfer.

Indexed as

Genetic VariationMultigene FamilyBacterial ToxinsDNA, BacterialEnterotoxigenic Escherichia coliEscherichia coli ProteinsFimbriae, BacterialMolecular Sequence DataSequence Analysis, DNASequence Homology, Amino AcidBacterial ToxinsDNA, BacterialEscherichia coli ProteinsLngA protein, E coli

Identifiers

PMID17951389
PMCPMC2168600

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.