ArticleThe American journal of cardiology2007
Incidence of coronary artery disease in siblings of patients with premature coronary artery disease: 10 years of follow-up.
Article in The American journal of cardiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 5 syntheses or guidelines pooled it, 95 citations in OpenAlex.
- Research inefficiencies in external validation studies of the Framingham Wilson coronary heart disease risk rule: A systematic review.PloS one · 2024Pooled it
- Performance of the Framingham risk models and pooled cohort equations for predicting 10-year risk of cardiovascular disease: a systematic review and meta-analysis.BMC medicine · 2019Pooled it
- Pooled it
- Sex differences in diabetes and risk of incident coronary artery disease in healthy young and middle-aged adults.Diabetes care · 2014Pooled it
- Association of C47T polymorphism in SOD2 gene with coronary artery disease: a case-control study and a meta-analysis.Molecular biology reports · 2012Pooled it
- THSD7A Exacerbates Atherosclerosis via Activation of Signaling Axis αvβ3/CEBPD/IL1A.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Increased VWF-to-ADAMTS13 ratio is associated with large cerebral white matter hyperintensities.Blood vessels, thrombosis & hemostasis · 2026Article
- Secondary analyses for genome-wide association studies using expression quantitative trait loci.Genetic epidemiology · 2022Article
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- Transcriptional profile of platelets and iPSC-derived megakaryocytes from whole-genome and RNA sequencing.Blood · 2021Article
- Cerebral Small-Vessel Disease in Individuals with a Family History of Coronary Heart Disease: The Atherosclerosis Risk in Communities Study.Neuroepidemiology · 2021Article
- A cardiovascular disease risk prediction algorithm for use with the Medicare current beneficiary survey.Health services research · 2020Article
- Premature Myocardial Infarction: Genetic Variations in SIRT1 Affect Disease Susceptibility.Cardiology research and practice · 2019Article
- Diabetes and Platelet Response to Low-Dose Aspirin.The Journal of clinical endocrinology and metabolism · 2018Article
- Impact of genetic polymorphisms on platelet function and response to anti platelet drugs.Cardiovascular diagnosis and therapy · 2018Review
- Genome-Wide Association Study of Heavy Smoking and Daily/Nondaily Smoking in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2018Article
- Age differences in periventricular and deep white matter lesions.Neurobiology of aging · 2015Article
- Greater collagen-induced platelet aggregation following cyclooxygenase 1 inhibition predicts incident acute coronary syndromes.Clinical and translational science · 2015Article
- Noncalcified coronary plaque volumes in healthy people with a family history of early onset coronary artery disease.Circulation. Cardiovascular imaging · 2014Article
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Although family history of premature coronary artery disease (CAD) confers increased risk of CAD, the magnitude of this increase beyond that expected from the risk factors incorporated in the Framingham Risk Equation (FRE) remains unknown. We prospectively determined the accuracy of the FRE 10-year incident CAD events prediction in initially healthy siblings of patients with documented premature CAD. We recruited 784 siblings (30 to 59 years) of 449 patients hospitalized with CAD <60 years of age (1983 to 1995). We compared the estimated 10-year incidence of total CAD events by the gender-specific FREs at baseline, to the observed incidence at 10 years of follow-up. In men, the 10-year actual CAD event rate was 20%, only half of which was predicted by the FRE (12% vs 20%, p <0.001). In women, the observed CAD event rate was 7.1% (p <0.001 vs men), modestly but not significantly greater than the 6.3% predicted by the FRE (p = 0.34). Thus, there was a significant 66.6% excess risk in men, and a nonsignificant 12.7% excess risk in women beyond the risk predicted by the FRE for total CAD events. The FRE and its known classic risk factor profile failed to accurately predict total incident 10-year CAD events in individuals with a sibling history of premature CAD, most particularly in men. In conclusion, in families with a history of premature CAD, the excess risk observed cannot be attributed to traditional risk factors, suggesting a major role for as yet undetermined genetic and other susceptibility factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.