ArticleFungal genetics and biology : FG & B2008
GLN3 encodes a global regulator of nitrogen metabolism and virulence of C. albicans.
Article in Fungal genetics and biology : FG & B, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 52 citations in OpenAlex.
- A multi-omics analysis unveils functional and regulatory links between hydroxybenzene and aromatic amino acid metabolism inmSystems · 2025Article
- Alternative sulphur metabolism in the fungal pathogen Candida parapsilosis.Nature communications · 2024Article
- Physiological, molecular, and environmental insights into plant nitrogen uptake, and metabolism under abiotic stresses.The plant genome · 2024Review
- Proteomics ofJournal of fungi (Basel, Switzerland) · 2023Article
- Amino Acid Sensing and Assimilation by the Fungal PathogenPathogens (Basel, Switzerland) · 2021Review
- Correction: Glutamate dehydrogenase (Gdh2)-dependent alkalization is dispensable for escape from macrophages and virulence of Candida albicans.PLoS pathogens · 2021Article
- Transcriptome Analysis Unveils Gln3 Role in Amino Acids Assimilation and Fluconazole Resistance inJournal of microbiology and biotechnology · 2021Article
- Glutamate dehydrogenase (Gdh2)-dependent alkalization is dispensable for escape from macrophages and virulence of Candida albicans.PLoS pathogens · 2020Article
- Mitochondrial proline catabolism activates Ras1/cAMP/PKA-induced filamentation in Candida albicans.PLoS genetics · 2019Article
- Overview of carbon and nitrogen catabolite metabolism in the virulence of human pathogenic fungi.Molecular microbiology · 2018Review
- Article
- Ribosomal protein S6 phosphorylation is controlled by TOR and modulated by PKA in Candida albicans.Molecular microbiology · 2015Article
- Article
- Diverse Hap43-independent functions of the Candida albicans CCAAT-binding complex.Eukaryotic cell · 2013Article
- The Ustilago maydis Nit2 homolog regulates nitrogen utilization and is required for efficient induction of filamentous growth.Eukaryotic cell · 2012Article
- Rhb1 regulates the expression of secreted aspartic protease 2 through the TOR signaling pathway in Candida albicans.Eukaryotic cell · 2012Article
- A GATA transcription factor recruits Hda1 in response to reduced Tor1 signaling to establish a hyphal chromatin state in Candida albicans.PLoS pathogens · 2012Article
- Characterization of an Nmr homolog that modulates GATA factor-mediated nitrogen metabolite repression in Cryptococcus neoformans.PloS one · 2012Article
- The Candida albicans GAP gene family encodes permeases involved in general and specific amino acid uptake and sensing.Eukaryotic cell · 2011Article
- Nitrogen metabolite repression of metabolism and virulence in the human fungal pathogen Cryptococcus neoformans.Genetics · 2011Article
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3 authors at 1 institution in 1 country.
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Abstract
The function of GLN3, a GATA factor encoding gene, in nitrogen metabolism of Candida albicans was examined. GLN3 null mutants had reduced growth rates on multiple nitrogen sources. More severe growth defects were observed in mutants lacking both GLN3 and GAT1, a second GATA factor gene. GLN3 was an activator of two genes involved in ammonium assimilation, GDH3, encoding NADP-dependent glutamate dehydrogenase, and MEP2, which encodes an ammonium permease. GAT1 contributed to MEP2 expression, but not that of GDH3. A putative general amino acid permease gene, GAP2, was also activated by both GLN3 and GAT1, but activation by GLN3 was nitrogen source dependent. GLN3 was constitutively expressed, but GAT1 expression varied with nitrogen source and was reduced 2- to 3-fold in gln3 mutants. Both gln3 and gat1 mutants exhibited reduced sensitivity to rapamycin, suggesting they function downstream of TOR kinase. Hyphae formation by gln3 and gat1 mutants differed in relation to nitrogen source. The gln3 mutants formed hyphae on several nitrogen sources, but not ammonium or urea, suggesting a defect in ammonium assimilation. Virulence of gln3 mutants was reduced in a murine model of disseminated disease. We conclude that GLN3 has a broad role in nitrogen metabolism, partially overlapping, but distinct from that of GAT1, and that its function is important for the ability of C. albicans to survive within the host environment.
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