Evidence map›Paper›PMID 17949693›Full record

SynthesisBiological psychiatry2008

Serotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysis.

Marcus R Munafò, Sarah M Brown, Ahmad R Hariri

Erratum issuedOpen access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Biological psychiatry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 310 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
310citing papers in PubMed, 11 pooled it
21.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

310 citing papers in PubMed, 11 syntheses or guidelines pooled it, 788 citations in OpenAlex.

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  10. Multi-cultural association of the serotonin transporter gene (SLC6A4) with substance use disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013
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  15. Comparing engage with PST in late-life major depression: a preliminary report.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2015
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  18. Candidate gene studies of a promising intermediate phenotype: failure to replicate.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013
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250 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Marcus R MunafòDepartment of Experimental Psychology, University of Bristol, United Kingdom. marcus.munafo@bristol.ac.uk
Sarah M Brown
Ahmad R Hariri
University of Bristol · GB

Funding

Development of Amygdala-Prefrontal InteractionsK01MH072837 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HARIRI, AHMAD R. · 2005 to 2009
$798k
NIMH NIH HHS K01 MH072837
6 · The paper itself

Abstract

backgroundWe evaluated the magnitude of the reported associations between amygdala activation and the serotonin transporter gene linked polymorphic region (5-HTTLPR) and the likely effect size of this relationship.

methodsWe used meta-analytic techniques to combine data from existing published and unpublished studies. We also tested for possible publication bias and explored possible moderating influences on any association, such as sample ancestry.

resultsOur results provide support for the association of the 5-HTTLPR polymorphism and amygdala activation and suggest that this locus may account for up to 10% of phenotypic variance. Although we did not observe evidence for potential publication bias in our main analysis, this was due in part to efforts to obtain unpublished data pertinent to this meta-analysis, and when three unpublished data sets were excluded we did observe evidence of such bias. We also observed evidence that the first published study may provide an overestimate of the true effect size, which is consistent with findings from genetic association studies of other phenotypes.

conclusionsAlthough our analysis provides support for the association of the 5-HTTLPR polymorphism and amygdala activation, it also suggests that most studies to date are nevertheless lacking in statistical power. Increasing the sample sizes of future imaging genetics studies will allow a more accurate characterization of any true effect size and afford adequate power to examine the impact of multiple polymorphisms that likely work in concert to affect gene function and, in turn, bias neural processes mediating dispositional traits such as temperament and personality.

Indexed as

GenotypeAdolescentAdultAllelesAmygdalaAnxiety DisordersDepressive DisorderFemaleHumansIndividualityMagnetic Resonance ImagingMalePhenotypePolymorphism, GeneticPromoter Regions, GeneticSerotonin Plasma Membrane Transport ProteinsSerotonin Plasma Membrane Transport Proteins

Identifiers

PMID17949693
PMCPMC2755289
OpenAlexW1991731575

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.