ArticleJournal of neurochemistry2008
Rapid estrogen regulation of DHEA metabolism in the male and female songbird brain.
Article in Journal of neurochemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 51 citations in OpenAlex.
- Dehydroepiandrosterone (DHEA) as a tool for conservation.Environmental monitoring and assessment · 2026Review
- Neuroendocrine Mechanisms Underlying Non-breeding Aggression: Common Strategies Between Birds and Fish.Frontiers in neural circuits · 2021Review
- Prospects for sociogenomics in avian cooperative breeding and parental care.Current zoology · 2020Article
- Melatonin mediates seasonal transitions in aggressive behavior and circulating androgen profiles in male Siberian hamsters.Hormones and behavior · 2020Article
- Rapid effects of 17β-estradiol on aggressive behavior in songbirds: Environmental and genetic influences.Hormones and behavior · 2018Review
- 3β-HSD expression in the CNS of a manakin and finch.General and comparative endocrinology · 2018Article
- On the role of brain aromatase in females: why are estrogens produced locally when they are available systemically?Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2018Review
- Aggressive behaviours track transitions in seasonal phenotypes of female Siberian hamsters.Functional ecology · 2017Article
- A Quantification of the Injury-Induced Changes in Central Aromatase, Oestrogenic Milieu and Steroid Receptor Expression in the Zebra Finch.Journal of neuroendocrinology · 2016Article
- Sex steroid profiles and pair-maintenance behavior of captive wild-caught zebra finches (Taeniopygia guttata).Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2016Article
- Rapid Effects of Estradiol on Aggression in Birds and Mice: The Fast and the Furious.Integrative and comparative biology · 2015Review
- Sex differences and rapid estrogen signaling: A look at songbird audition.Frontiers in neuroendocrinology · 2015Review
- Reproductive state modulates testosterone-induced singing in adult female European starlings (Sturnus vulgaris).Hormones and behavior · 2015Article
- Relationships between rapid changes in local aromatase activity and estradiol concentrations in male and female quail brain.Hormones and behavior · 2014Article
- New biosynthesis and biological actions of avian neurosteroids.Journal of experimental neuroscience · 2013Review
- Neurosteroidogenesis: insights from studies of songbirds.Journal of neuroendocrinology · 2012Review
- Measurement of steroid concentrations in brain tissue: methodological considerations.Frontiers in endocrinology · 2011Article
- Neurosteroid biosynthesis and function in the brain of domestic birds.Frontiers in endocrinology · 2011Article
- Steroid concentrations in plasma, whole blood and brain: effects of saline perfusion to remove blood contamination from brain.PloS one · 2010Article
- Diversity of mechanisms involved in aromatase regulation and estrogen action in the brain.Biochimica et biophysica acta · 2010Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In the songbird brain, dehydroepiandrosterone (DHEA) is metabolized to the active and aromatizable androgen androstenedione (AE) by 3beta-hydroxysteroid dehydrogenase/Delta5-Delta4 isomerase (3beta-HSD). Thus, brain 3beta-HSD plays a key role in regulating the steroidal milieu of the nervous system. Previous studies have shown that stress rapidly regulates brain 3beta-HSD activity in a sex-specific manner. To elucidate endocrine regulation of brain 3beta-HSD, we asked whether 17beta-estradiol (E(2)) regulates DHEA metabolism in adult zebra finch (Taeniopygia guttata) and whether there are sex-specific effects. Brain tissue was homogenized and centrifuged to obtain supernatant lacking whole cells and cell nuclei. Supernatant was incubated with [(3)H]DHEA and radioinert E(2)in vitro. Within only 10 min, E(2) significantly reduced 3beta-HSD activity in both male and female brain. Interestingly, the rapid effects of E(2) were more pronounced in females than males. These are the first data to show a rapid effect of estrogens on the songbird brain and suggest that rapid estrogen effects differ between male and female brains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.