ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2008
Dopaminergic mutations: within-family association and linkage in multiplex alcohol dependence families.
Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 54 citations in OpenAlex.
- DRD2 and DRD4 genes related to cognitive deficits in HIV-infected adults who abuse alcohol.Behavioral and brain functions : BBF · 2015Trial
- Morbidity and mortality in alcohol use disorder: the role of comorbid substance use disorder, age, sex, and the A1 allele of the Taq1A (rs1800497) polymorphism in the ANKK1 gene in an 18-year follow-up.Alcohol and alcoholism (Oxford, Oxfordshire) · 2026Article
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- Article
- The DRD2 Taq1A A1 Allele May Magnify the Risk of Alzheimer's in Aging African-Americans.Molecular neurobiology · 2018Review
- The impact of common dopamine D2 receptor gene polymorphisms on D2/3 receptor availability: C957T as a key determinant in putamen and ventral striatum.Translational psychiatry · 2017Article
- Longitudinal predictors of cannabis use and dependence in offspring from families at ultra high risk for alcohol dependence and in control families.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2016Article
- Updated findings of the association and functional studies of DRD2/ANKK1 variants with addictions.Molecular neurobiology · 2015Article
- Genetic Addiction Risk Score (GARS): molecular neurogenetic evidence for predisposition to Reward Deficiency Syndrome (RDS).Molecular neurobiology · 2014Article
- Alcohol abuse and HIV infection: role of DRD2.Current HIV research · 2014Article
- Caudate Volume in Offspring at Ultra High Risk for Alcohol Dependence: COMT Val158Met, DRD2, Externalizing Disorders, and Working Memory.Advances in molecular imaging · 2013Article
- Dopamine Genetics and Function in Food and Substance Abuse.Journal of genetic syndromes & gene therapy · 2013Article
- Systematic analysis of dopamine receptor genes (DRD1-DRD5) in antipsychotic-induced weight gain.The pharmacogenomics journal · 2012Article
- Generational association studies of dopaminergic genes in reward deficiency syndrome (RDS) subjects: selecting appropriate phenotypes for reward dependence behaviors.International journal of environmental research and public health · 2011Article
- Adolescents at risk for alcohol abuse demonstrate altered frontal lobe activation during Stroop performance.Alcoholism, clinical and experimental research · 2011Article
- Article
- A polymorphism in the dysbindin gene (DTNBP1) associated with multiple psychiatric disorders including schizophrenia.Behavioral and brain functions : BBF · 2010Article
- Sweet preferences and analgesia during childhood: effects of family history of alcoholism and depression.Addiction (Abingdon, England) · 2010Article
- Neurogenetics of dopaminergic receptor supersensitivity in activation of brain reward circuitry and relapse: proposing "deprivation-amplification relapse therapy" (DART).Postgraduate medicine · 2009Review
- Relationship between white matter volume and cognitive performance during adolescence: effects of age, sex and risk for drug use.Addiction (Abingdon, England) · 2008Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Animal and human studies of addiction indicate that the D2 dopamine receptor (DRD2) plays a critical role in the mechanism of drug reward. D2 receptor density in the brains of alcoholics has been shown to be reduced relative to controls. Previous studies of DRD2 in association with alcohol dependence using variation in the TaqI A locus were highly controversial. Recently, a synonymous mutation, C957T, in the coding region of the human DRD2 gene has been identified which appears to have functional effects including alteration in receptor availability. In order to determine if susceptibility to alcohol dependence (AD) within multiplex alcohol dependence families would be altered by the C957T in the coding region of the D2 gene, within-family association was studied in members of Caucasian multiplex alcohol dependence families. Members of control families with no personal alcohol or substance dependence history were included for case/control comparisons. Analyses performed to detect within-family association showed evidence favoring an association for the C957T polymorphism (P = 0.038). Linkage analyses of polymorphisms in this region showed that only the C957T locus remained of interest (P = 0.015). Evidence for the C957T T allele having a role in AD susceptibility at the population level using a case/control comparison was statistically marginal (P = 0.062), but was consistent with the family data results. These results support a role for DRD2 as a susceptibility gene for alcohol dependence within multiplex families at high risk for developing alcohol dependence.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.