ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2007
dTrf2 is required for transcriptional and developmental responses to ecdysone during Drosophila metamorphosis.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- High-resolution binding data of TFIID and cofactors show promoter-specific differences in vivo.Research square · 2026Article
- High-resolution binding data of TFIID and cofactors show promoter-specific differencesbioRxiv : the preprint server for biology · 2025Article
- Article
- The Core Promoter Is a Regulatory Hub for Developmental Gene Expression.Frontiers in cell and developmental biology · 2021Review
- Visualization of insect metamorphosis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- Drosophila TRF2 and TAF9 regulate lipid droplet size and phospholipid fatty acid composition.PLoS genetics · 2017Article
- Australian black field crickets show changes in neural gene expression associated with socially-induced morphological, life-history, and behavioral plasticity.BMC genomics · 2016Article
- Digitor/dASCIZ Has Multiple Roles in Drosophila Development.PloS one · 2016Article
- TRF2: TRansForming the view of general transcription factors.Transcription · 2015Review
- Drosophila TRF2 is a preferential core promoter regulator.Genes & development · 2014Article
- Ash2 acts as an ecdysone receptor coactivator by stabilizing the histone methyltransferase Trr.Molecular biology of the cell · 2013Article
- LMNA variants cause cytoplasmic distribution of nuclear pore proteins in Drosophila and human muscle.Human molecular genetics · 2012Article
- The Polycomb group protein CRAMPED is involved with TRF2 in the activation of the histone H1 gene.Chromosoma · 2011Article
- Unexpected roles for core promoter recognition factors in cell-type-specific transcription and gene regulation.Nature reviews. Genetics · 2010Review
- Promoting developmental transcription.Development (Cambridge, England) · 2010Review
- A genetic screen identifies new regulators of steroid-triggered programmed cell death in Drosophila.Genetics · 2008Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
The TATA box-binding protein (TBP) related factor 2 (TRF2) has been well characterized at a biochemical level and in cultured cells. Relatively little, however, is known about how TRF2 functions in specific biological pathways during development. Here, we show that Drosophila TRF2 (dTRF2) plays an essential role in responses to the steroid hormone ecdysone during the onset of metamorphosis. Hypomorphic dTrf2 mutations lead to developmental arrest during prepupal and early pupal stages with defects in major ecdysone-triggered biological responses, including puparium formation, anterior spiracle eversion, gas bubble translocation, adult head eversion, and larval salivary gland cell death. The transcription of key ecdysone-regulated target genes is delayed and reduced in dTrf2 mutants. dTrf2 appears to be required for the proper timing and levels of ecdysone-regulated gene expression required for entry into metamorphosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.