Trial reportTexas Heart Institute journal2007
Oral ascorbic acid in combination with beta-blockers is more effective than beta-blockers alone in the prevention of atrial fibrillation after coronary artery bypass grafting.
Trial report in Texas Heart Institute journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 39 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Advancing the Cardiovascular Science of Vitamin C in Cardiac Surgery Patients
The Synergistic Action of Vitamins and Dietary Supplements in Patients With Coronary Artery Bypass Grafting for Improving the Quality of Healthcare Delivery.
Who cites it
39 citing papers in PubMed, 4 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- Effects of Vitamin C on Organ Function in Cardiac Surgery Patients: A Systematic Review and Meta-Analysis.Nutrients · 2019Pooled it
- Pooled it
- Sole and combined vitamin C supplementation can prevent postoperative atrial fibrillation after cardiac surgery: A systematic review and meta-analysis of randomized controlled trials.Clinical cardiology · 2018Pooled it
- Vitamin C for preventing atrial fibrillation in high risk patients: a systematic review and meta-analysis.BMC cardiovascular disorders · 2017Pooled it
- The combined effect of statin and vitamin C in patients with pulmonary septic shock: a single-center, double-blind clinical trial.BMC infectious diseases · 2025Trial
- Oxidative stress and atrial fibrillation.Journal of molecular and cellular cardiology · 2024Review
- Preoperative and postoperative administration of vitamin C in cardiac surgery patients - settings, dosages, duration, and clinical outcomes: a narrative review.Annals of medicine and surgery (2012) · 2024Review
- Effect of Perioperative Oral Vitamin C Supplementation on In-Hospital Postoperative Medication Costs for Cardiac Surgery Patients: A Prospective, Single-Centre, Randomised Clinical Trial.PharmacoEconomics - open · 2023Article
- Use of complementary or alternative medicine and potential interactions with chronic medications among Chinese survivors of childhood cancer.Journal of cancer survivorship : research and practice · 2022Article
- Rare and intractable fibrodysplasia ossificans progressiva shows different PBMC phenotype possibly modulated by ascorbic acid and propranolol treatment.Intractable & rare diseases research · 2021Article
- Novel Combined Antioxidant Strategy against Hypertension, Acute Myocardial Infarction and Postoperative Atrial Fibrillation.Biomedicines · 2021Review
- Correction: Hill, A.; et al. Effects of Vitamin C on Organ Function in Cardiac Surgery Patients: A Systematic Review and Meta-Analysis.Nutrients · 2020Article
- Novel beta-blocker pretreatment prevents alcohol-induced atrial fibrillation in a rat model.Heart rhythm O2 · 2020Article
- Postoperative Atrial Fibrillation Following Cardiac Surgery: From Pathogenesis to Potential Therapies.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2020Review
- Propranolol and ascorbic acid in control of fibrodysplasia ossificans progressiva flare-ups due to accidental falls.Intractable & rare diseases research · 2019Article
- Vitamin C to Improve Organ Dysfunction in Cardiac Surgery Patients-Review and Pragmatic Approach.Nutrients · 2018Review
- New-onset atrial fibrillation: an update.Journal of anesthesia · 2018Review
- Vitamin C supplementation in the critically ill: A systematic review and meta-analysis.SAGE open medicine · 2018Review
- Association between oxidative stress and atrial fibrillation.Heart rhythm · 2017Article
- Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes.Cardiovascular diabetology · 2017Review
Corrections and comments
- Commented on by
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Because adrenergic beta antagonists are not sufficient to prevent atrial fibrillation after coronary artery bypass grafting, this prospective, randomized trial was designed to evaluate the effects of ascorbic acid as an adjunct to beta-blockers. Fifty patients formed our ascorbic acid group, and another 50 patients formed our control group. All patients were older than 50 years, were scheduled to undergo coronary artery bypass grafting, and had been treated with beta-blockers for at least 1 week before surgery. The mean age of the population was 60.19+/-7.14 years; 67% of the patients were men. Patients in the ascorbic acid group received 2 g of ascorbic acid on the night before the surgery and 1 g twice daily for 5 days after surgery. Patients in the control group received no ascorbic acid. Patients in both groups continued to receive beta-blockers after surgery. Telemetry monitoring was performed in the intensive care unit, and Holter monitoring was performed for 4 days thereafter. The incidence of postoperative atrial fibrillation was 4% in the ascorbic acid group and 26% in the control group (odds ratio, 0.119; 95% confidence interval, 0.025-0.558, P = 0.002). We conclude that ascorbic acid is effective, in addition to being well-tolerated and relatively safe. Therefore, it can be prescribed as an adjunct to beta-blockers for the prophylaxis of post-bypass atrial fibrillation.
Indexed as
Identifiers
17948074PMC1995047W1534173372What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.