Evidence map›Paper›PMID 17948027›Full record

ReviewCell death and differentiation2008

Interactions of tumor cells with dendritic cells: balancing immunity and tolerance.

M V Dhodapkar, K M Dhodapkar, A K Palucka

Abstract readReview
In one paragraph

Review in Cell death and differentiation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed.

  1. Trial
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  5. Article
  6. Microenvironment-based immunotherapy in oral cancer: a comprehensive review.Medical oncology (Northwood, London, England) · 2025
    Review
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  9. Article
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  11. Article
  12. Article
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  17. Adhesion molecules in multiple myeloma oncogenesis and targeted therapy.International journal of hematologic oncology · 2022
    Review
  18. Review
  19. Review
  20. Review

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

M V DhodapkarLaboratory of Tumor Immunology and Immunotherapy, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA. dhodapm@rockefeller.edu
K M Dhodapkar
A K Palucka

Funding

Regulation by the Immune Response to Vaccines by BotanicalsP50AT002779 · NCCIH · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI CHEUNG, NAI-KONG V · 2005 to 2009
$7.2M
Anti-Tumor immunity in myelomaR01CA106802 · NCI · YALE UNIVERSITY · PI DHODAPKAR, MADHAV V · 2004 to 2016
$3.3M
SUBPOPULATIONS OF HUMAN DENDRITIC CELLSR01CA078846 · NCI · BAYLOR RESEARCH INSTITUTE · PI BANCHEREAU, JACQUES F · 1999 to 2008
$2.5M
Targeting myeloma via dendritic cellsR01CA109465 · NCI · YALE UNIVERSITY · PI DHODAPKAR, MADHAV V · 2005 to 2009
$1.6M
Dendritic Cells and Breast Cancer ImmunityR01CA089440 · NCI · BAYLOR RESEARCH INSTITUTE · PI PALUCKA, ANNA KAROLINA · 2001 to 2004
$930k
Immune resistance to glioma via dendritic cellsK08AI054375 · NIAID · YALE UNIVERSITY · PI DHODAPKAR, KAVITA MADHAV · 2004 to 2008
$631k
NCCIH NIH HHS AT 02779NCI NIH HHS CA 078846NCI NIH HHS CA 106802NCI NIH HHS CA109465NCI NIH HHS P01 CA 084514NCI NIH HHS R01 CA078846NCI NIH HHS R01 CA 089440NCI NIH HHS R01 CA089440NCI NIH HHS R01 CA106802NCI NIH HHS R01 CA109465NIAID NIH HHS AI 054375NIAID NIH HHS K08 AI054375
6 · The paper itself

Abstract

Dendritic cells (DCs) are antigen-presenting cells specialized to initiate and maintain immunity and tolerance. DCs initiate immune responses in a manner that depends on signals they receive from pathogens, surrounding cells and their products. Most tumors are infiltrated by DCs. Thus, interactions between DCs and dying tumor cells may determine the balance between immunity and tolerance to tumor cells. In addition, DCs also display non-immunologic effects on tumors and the tumor microenvironment. Therefore, improved understanding of the cross talk between tumor cells and DCs may suggest new approaches to improve cancer therapy.

Indexed as

AnimalsCell DeathCytokinesDendritic CellsHumansImmune ToleranceImmunity, CellularImmunotherapyNeoplasmsReceptors, Cell SurfaceSignal TransductionT-Lymphocytes, RegulatoryToll-Like ReceptorsCytokinesReceptors, Cell SurfaceToll-Like Receptors

Identifiers

PMID17948027
PMCPMC2762352

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.