ArticleJournal of immunology (Baltimore, Md. : 1950)2007
Cutting edge: TCR revision affects predominantly Foxp3 cells and skews them toward the Th17 lineage.
Article in Journal of immunology (Baltimore, Md. : 1950), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 19 citations in OpenAlex.
- Of the multiple mechanisms leading to type 1 diabetes, T cell receptor revision may play a prominent role (is type 1 diabetes more than a single disease?).Clinical and experimental immunology · 2016Review
- High antigen levels induce an exhausted phenotype in a chronic infection without impairing T cell expansion and survival.The Journal of experimental medicine · 2016Article
- Receptor revision in CD4 T cells is influenced by follicular helper T cell formation and germinal-center interactions.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- CD40 interacts directly with RAG1 and RAG2 in autoaggressive T cells and Fas prevents CD40-induced RAG expression.Cellular & molecular immunology · 2013Article
- The dynamic lives of T cells: new approaches and themes.Trends in immunology · 2013Review
- Bcl-2-interacting mediator of cell death influences autoantigen-driven deletion and TCR revision.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- TCR revision generates functional CD4+ T cells.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- T-cell receptor revision: friend or foe?Immunology · 2010Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
CD4(+) T cells respond to peripheral endogenous superantigen stimulation by undergoing deletion or TCR revision. The latter involves RAG re-expression, TCR gene rearrangement, and expression of a novel TCR. TCR-revised T cells are functional and express a diverse TCR repertoire. Because TCR revision harbors the potential to create self-reactivity, it is important to explore whether T cells known to be self-reactive (regulatory T cells) or those involved in autoimmunity (Th17 cells) arise from TCR revision. Interestingly, we observed that Foxp3(+) cells are excluded from revising their TCR and that only a small fraction of postrevision cells expresses Foxp3. In contrast, Th17 cells are 20 times more frequent among revised than among C57BL/6 CD4(+) T cells, indicating that postrevision cells are biased toward the Th17 lineage. The link between Th17 differentiation and TCR revision might be highly relevant to the role of Th17 cells in promoting autoimmunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.