ArticleGenetics2007
An unusually low microsatellite mutation rate in Dictyostelium discoideum, an organism with unusually abundant microsatellites.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- Global and Local Ancestry and its Importance: A Review.Current genomics · 2024Review
- Very Low Rates of Spontaneous Gene Deletions and Gene Duplications in Dictyostelium discoideum.Journal of molecular evolution · 2023Article
- Insights on Microsatellite Characteristics, Evolution, and Function From the Social AmoebaFrontiers in neuroscience · 2022Review
- Review
- Low Base-Substitution Mutation Rate but High Rate of Slippage Mutations in the Sequence Repeat-Rich Genome ofG3 (Bethesda, Md.) · 2020Article
- Mode and Tempo of Microsatellite Length Change in a Malaria Parasite Mutation Accumulation Experiment.Genome biology and evolution · 2019Article
- Article
- The exact distributions of F(IS) under partial asexuality in small finite populations with mutation.PloS one · 2014Article
- The rate and effects of spontaneous mutation on fitness traits in the social amoeba, Dictyostelium discoideum.G3 (Bethesda, Md.) · 2013Article
- Microsatellites as targets of natural selection.Molecular biology and evolution · 2013Article
- Variation in heterozygosity predicts variation in human substitution rates between populations, individuals and genomic regions.PloS one · 2013Article
- Amino acid repeats cause extraordinary coding sequence variation in the social amoeba Dictyostelium discoideum.PloS one · 2012Article
- Whole genome sequencing of mutation accumulation lines reveals a low mutation rate in the social amoeba Dictyostelium discoideum.PloS one · 2012Article
- Characterization and comparison of gene-based simple sequence repeats across Brassica species.Molecular genetics and genomics : MGG · 2011Article
- The narrow endemic Norwegian peat moss Sphagnum troendelagicum originated before the last glacial maximum.Heredity · 2011Article
- Length polymorphism and head shape association among genes with polyglutamine repeats in the stalk-eyed fly, Teleopsis dalmanni.BMC evolutionary biology · 2010Article
- Variation, sex, and social cooperation: molecular population genetics of the social amoeba Dictyostelium discoideum.PLoS genetics · 2010Article
- Mutational dynamics of microsatellites.Molecular biotechnology · 2010Review
- Sequence determinants of human microsatellite variability.BMC genomics · 2009Article
- Kin discrimination increases with genetic distance in a social amoeba.PLoS biology · 2008Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The genome of the social amoeba Dictyostelium discoideum is known to have a very high density of microsatellite repeats, including thousands of triplet microsatellite repeats in coding regions that apparently code for long runs of single amino acids. We used a mutation accumulation study to see if unusually high microsatellite mutation rates contribute to this pattern. There was a modest bias toward mutations that increase repeat number, but because upward mutations were smaller than downward ones, this did not lead to a net average increase in size. Longer microsatellites had higher mutation rates than shorter ones, but did not show greater directional bias. The most striking finding is that the overall mutation rate is the lowest reported for microsatellites: approximately 1 x 10(-6) for 10 dinucleotide loci and 6 x 10(-6) for 52 trinucleotide loci (which were longer). High microsatellite mutation rates therefore do not explain the high incidence of microsatellites. The causal relation may in fact be reversed, with low mutation rates evolving to protect against deleterious fitness effects of mutation at the numerous microsatellites.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.