ArticleGenetics2007
Interspecific recombinant congenic strains between C57BL/6 and mice of the Mus spretus species: a powerful tool to dissect genetic control of complex traits.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Identification of a New QTL Region on Mouse Chromosome 1 Responsible for Male Hypofertility: Phenotype Characterization and Candidate Genes.International journal of molecular sciences · 2020Article
- Large-scale discovery of male reproductive tract-specific genes through analysis of RNA-seq datasets.BMC biology · 2020Article
- The multisystemic functions of FOXD1 in development and disease.Journal of molecular medicine (Berlin, Germany) · 2018Review
- Genetic mapping of species differences via in vitro crosses in mouse embryonic stem cells.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Whole exome sequencing of wild-derived inbred strains of mice improves power to link phenotype and genotype.Mammalian genome : official journal of the International Mammalian Genome Society · 2017Article
- Innate Immune Basis for Rift Valley Fever Susceptibility in Mouse Models.Scientific reports · 2017Article
- Association of FOXD1 variants with adverse pregnancy outcomes in mice and humans.Open biology · 2016Article
- A multi-megabase copy number gain causes maternal transmission ratio distortion on mouse chromosome 2.PLoS genetics · 2015Article
- Quantitative genetics in the study of virus-induced disease.Advances in virus research · 2014Review
- Resistance to plague of Mus spretus SEG/Pas mice requires the combined action of at least four genetic factors.Genes and immunity · 2013Article
- Chromosome substitution strains: gene discovery, functional analysis, and systems studies.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Review
- Exploration of the genetic organization of morphological modularity on the mouse mandible using a set of interspecific recombinant congenic strains between C57BL/6 and mice of the Mus spretus species.G3 (Bethesda, Md.) · 2012Article
- Nasal bone shape is under complex epistatic genetic control in mouse interspecific recombinant congenic strains.PloS one · 2012Article
- Refined mapping of a quantitative trait locus on chromosome 1 responsible for mouse embryonic death.PloS one · 2012Article
- Mapping quantitative traits and strategies to find quantitative trait genes.Methods (San Diego, Calif.) · 2011Review
- Fidgetin-like1 is a strong candidate for a dynamic impairment of male meiosis leading to reduced testis weight in mice.PloS one · 2011Article
- Article
- SYSGENET: a meeting report from a new European network for systems genetics.Mammalian genome : official journal of the International Mammalian Genome Society · 2010Article
- Adaptive evolution of interferon-gamma in Glire lineage and evidence for a recent selective sweep in Mus. m. domesticus.Genes and immunity · 2009Article
- Gene expression regulation in the context of mouse interspecific mosaic genomes.Genome biology · 2008Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Complex traits are under the genetic control of multiple genes, often with weak effects and strong epistatic interactions. We developed two new collections of mouse strains to improve genetic dissection of complex traits. They are derived from several backcrosses of the Mus spretus SEG/Pas or STF/Pas strains on the C57BL/6J background. Each of the 55 interspecific recombinant congenic strains (IRCSs) carries up to eight SEG/Pas chromosomal segments with an average size of 11.7 Mb, totalizing 1.37% of the genome. The complete series covers 39.7% of the SEG/Pas genome. As a complementary resource, six partial or complete interspecific consomic strains were developed and increased genome coverage to 45.6%. To evaluate the usefulness of these strains for QTL mapping, 16 IRCSs were compared with C57BL/6J for seven hematological parameters. Strain 66H, which carries three SEG/Pas chromosomal segments, had lower red blood cell volume and higher platelet count than C57BL/6J. Each chromosomal segment was isolated in a congenic strain to evaluate individual effects. Congenic strains were combined to assess epistasis. Our data show that both traits were controlled by several genes with complex epistatic interactions. IRCSs are therefore useful to unravel QTL with small effects and gene-by-gene interactions.
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