ArticleGenetics2007
The formation of the central element of the synaptonemal complex may occur by multiple mechanisms: the roles of the N- and C-terminal domains of the Drosophila C(3)G protein in mediating synapsis and recombination.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 40 citations in OpenAlex.
- Structure and function of the synaptonemal complex.The Journal of cell biology · 2026Review
- The synaptonemal complex component corolla regulates meiotic crossover formation in Drosophila melanogaster.Chromosoma · 2025Article
- Diversification and recurrent adaptation of the synaptonemal complex in Drosophila.PLoS genetics · 2025Article
- Article
- Building the synaptonemal complex: Molecular interactions between the axis and the central region.PLoS genetics · 2023Review
- Synaptonemal Complex dimerization regulates chromosome alignment and crossover patterning in meiosis.PLoS genetics · 2021Article
- Identification of novel synaptonemal complex components in C. elegans.The Journal of cell biology · 2020Article
- Synaptonemal Complex-DeficientG3 (Bethesda, Md.) · 2020Article
- SYCP2 Translocation-Mediated Dysregulation and Frameshift Variants Cause Human Male Infertility.American journal of human genetics · 2020Article
- Article
- Centromeric SMC1 promotes centromere clustering and stabilizes meiotic homolog pairing.PLoS genetics · 2019Article
- The E3 ubiquitin ligase Sina regulates the assembly and disassembly of the synaptonemal complex in Drosophila females.PLoS genetics · 2019Article
- Combined expansion microscopy with structured illumination microscopy for analyzing protein complexes.Nature protocols · 2018Article
- Stonewall and Brickwall: Two Partially Redundant Determinants Required for the Maintenance of Female Germline inG3 (Bethesda, Md.) · 2018Article
- Regulating chromosomal movement by the cochaperone FKB-6 ensures timely pairing and synapsis.The Journal of cell biology · 2017Article
- Achiasmy: Male Fruit Flies Are Not Ready to Mix.Frontiers in cell and developmental biology · 2016Article
- Microtubule-driven nuclear rotations promote meiotic chromosome dynamics.Nature cell biology · 2015Article
- Article
- Corolla is a novel protein that contributes to the architecture of the synaptonemal complex of Drosophila.Genetics · 2014Article
- SUMO localizes to the central element of synaptonemal complex and is required for the full synapsis of meiotic chromosomes in budding yeast.PLoS genetics · 2013Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Drosophila melanogaster oocytes, the C(3)G protein comprises the transverse filaments (TFs) of the synaptonemal complex (SC). Like other TF proteins, such as Zip1p in yeast and SCP1 in mammals, C(3)G is composed of a central coiled-coil-rich domain flanked by N- and C-terminal globular domains. Here, we analyze in-frame deletions within the N- and C-terminal regions of C(3)G in Drosophila oocytes. As is the case for Zip1p, a C-terminal deletion of C(3)G fails to attach to the lateral elements of the SC. Instead, this C-terminal deletion protein forms a large cylindrical polycomplex structure. EM analysis of this structure reveals a polycomplex of concentric rings alternating dark and light bands. However, unlike both yeast and mammals, all three proteins deleted for N-terminal regions completely abolished both SC and polycomplex formation. Both the N- and C-terminal deletions significantly reduce or abolish meiotic recombination similarly to c(3)G null homozygotes. To explain these data, we propose that in Drosophila the N terminus, but not the C-terminal globular domain, of C(3)G is critical for the formation of antiparallel pairs of C(3)G homodimers that span the central region and thus for assembly of complete TFs, while the C terminus is required to affix these homodimers to the lateral elements.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.