ArticleGenetics2007
Genetic analyses of a hybrid cross between serotypes A and D strains of the human pathogenic fungus Cryptococcus neoformans.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 47 citations in OpenAlex.
- On the evolution of variation in sexual reproduction through the prism of eukaryotic microbes.Proceedings of the National Academy of Sciences of the United States of America · 2023Review
- Article
- ESA1 regulates meiotic chromosome axis and crossover frequency via acetylating histone H4.Nucleic acids research · 2021Article
- What Are the Best Parents for Hybrid Progeny? An Investigation into the Human Pathogenic FungusJournal of fungi (Basel, Switzerland) · 2021Article
- Construction of Genetic Linkage Maps From a Hybrid Family of Large Yellow Croaker (Frontiers in genetics · 2021Article
- Factors enforcing the species boundary between the human pathogens Cryptococcus neoformans and Cryptococcus deneoformans.PLoS genetics · 2021Article
- The evolving species concepts used for yeasts: from phenotypes and genomes to speciation networks.Fungal diversity · 2021Review
- The Pheromone and Pheromone Receptor Mating-Type Locus Is Involved in Controlling Uniparental Mitochondrial Inheritance inGenetics · 2020Article
- Review
- Genetic Changes in Experimental Populations of a Hybrid in thePathogens (Basel, Switzerland) · 2019Article
- The Evolution of Sexual Reproduction and the Mating-Type Locus: Links to Pathogenesis ofAnnual review of genetics · 2019Review
- Article
- Cryptococcus neoformans Mating and Genetic Crosses.Current protocols in microbiology · 2019Article
- Genotypic and Phenotypic Analyses of Two "Isogenic" Strains of the Human Fungal Pathogen Cryptococcus neoformans var. neoformans.Mycopathologia · 2019Article
- A High-Resolution Map of Meiotic Recombination inGenetics · 2018Article
- Cryptococcus neoformans can form titan-like cells in vitro in response to multiple signals.PLoS pathogens · 2018Article
- Genetic and environmental influences on the germination of basidiospores in the Cryptococcus neoformans species complex.Scientific reports · 2016Article
- Identification of QTLs Associated with Virulence Related Traits and Drug Resistance in Cryptococcus neoformans.G3 (Bethesda, Md.) · 2016Article
- From Two to One: Unipolar Sexual Reproduction.Fungal biology reviews · 2015Article
- Unisexual versus bisexual mating in Cryptococcus neoformans: Consequences and biological impacts.Fungal genetics and biology : FG & B · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cryptococcus neoformans has two varieties, var. grubii and var. neoformans, that correspond to serotypes A and D, respectively. Molecular phylogenetic analyses suggest that these two varieties have diverged from each other for approximately 18 million years. The discovery of pathogenic serotype AD hybrid strains in nature indicates that intervariety mating in C. neoformans occurs in the natural environment. However, little is known about the genetic consequences of hybridization in C. neoformans. Here, we analyzed a hybrid population of 163 progeny from a cross between strains of serotypes A (CDC15) and D (JEC20), using 114 codominant nuclear PCR-RFLP markers and 1 direct PCR marker. These markers were distributed on all 14 chromosomes of the sequenced strain JEC21 that was isogenic to one of the parents (JEC20) in our cross. Our analyses identified that of the 163 progeny, 5 were heterozygous at all 115 loci, 1 was completely homozygous and identical to one of the parents (CDC15), and the remaining 157 each contained at least 1 heterozygous locus. Because all 163 progeny inherited mitochondria from the MATa parent JEC20, none of the progeny had a genotype identical to either of the two parents or to a composite of the two parents. All 115 nuclear loci showed three different genotypes in the progeny population, consistent with Mendelian segregation during meiosis. While the linkage analysis showed independent reassortment among loci on different linkage groups, there were significant differences in recombination frequencies among chromosomes and among regions within certain chromosomes. Overall, the linkage-map length from this hybrid cross was much shorter and the recombination frequency much lower than those constructed using serotype D strains, consistent with suppressed recombination in the intervariety cross between strains of serotypes A and D. We discuss the implications of our results in our understanding of the speciation and evolution of the C. neoformans species complex.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.