ArticleGenetics2007
Circadian rhythm gene regulation in the housefly Musca domestica.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed.
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- Time of Day-Specific Changes in Metabolic Detoxification and Insecticide Tolerance in the House Fly,Frontiers in physiology · 2021Article
- Light input pathways to the circadian clock of insects with an emphasis on the fruit fly Drosophila melanogaster.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2020Review
- Flies as models for circadian clock adaptation to environmental challenges.The European journal of neuroscience · 2020Review
- Model and Non-model Insects in Chronobiology.Frontiers in behavioral neuroscience · 2020Review
- Localization and expression of putative circadian clock transcripts in the brain of the nudibranch Melibe leonina.Comparative biochemistry and physiology. Part A, Molecular & integrative physiology · 2018Article
- The characterization of the circadian clock in the olive fly Bactrocera oleae (Diptera: Tephritidae) reveals a Drosophila-like organization.Scientific reports · 2018Article
- Daily Activity of the Housefly,G3 (Bethesda, Md.) · 2017Article
- Characterization and Expression Pattern Analysis of the T-Complex Protein-1 Zeta Subunit in Musca domestica L (Diptera).Journal of insect science (Online) · 2017Article
- Transcriptomic analysis of the housefly (Musca domestica) larva using massively parallel pyrosequencing.Molecular biology reports · 2012Article
- Sleep, arousal, and rhythms in flies.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Cryptochromes define a novel circadian clock mechanism in monarch butterflies that may underlie sun compass navigation.PLoS biology · 2008Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
The circadian mechanism appears remarkably conserved between Drosophila and mammals, with basic underlying negative and positive feedback loops, cycling gene products, and temporally regulated nuclear transport involving a few key proteins. One of these negative regulators is PERIOD, which in Drosophila shows very similar temporal and spatial regulation to TIMELESS. Surprisingly, we observe that in the housefly, Musca domestica, PER does not cycle in Western blots of head extracts, in contrast to the TIM protein. Furthermore, immunocytochemical (ICC) localization using enzymatic staining procedures reveals that PER is not localized to the nucleus of any neurons within the brain at any circadian time, as recently observed for several nondipteran insects. However, with confocal analysis, immunofluorescence reveals a very different picture and provides an initial comparison of PER/TIM-containing cells in Musca and Drosophila, which shows some significant differences, but many similarities. Thus, even in closely related Diptera, there is considerable evolutionary flexibility in the number and spatial organization of clock cells and, indeed, in the expression patterns of clock products in these cells, although the underlying framework is similar.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.