ReviewToxicological sciences : an official journal of the Society of Toxicology2008
The vascular system as a target of metal toxicity.
Review in Toxicological sciences : an official journal of the Society of Toxicology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
109 citing papers in PubMed, 4 syntheses or guidelines pooled it, 328 citations in OpenAlex.
- The relationship between cadmium exposure and preeclampsia: a systematic review and meta-analysis.Frontiers in medicine · 2023Pooled it
- Systemic review of genetic and epigenetic factors underlying differential toxicity to environmental lead (Pb) exposure.Environmental science and pollution research international · 2022Pooled it
- Cadmium Exposure and Testis Susceptibility: a Systematic Review in Murine Models.Biological trace element research · 2021Pooled it
- Environmental Metals and Cardiovascular Disease in Adults: A Systematic Review Beyond Lead and Cadmium.Current environmental health reports · 2016Pooled it
- Cardioprotective effect of hydroalcoholic extract stem bark ofPharmaceutical biology · 2026Article
- Article
- Prenatal bisphenol A exposure reprograms SF1-lactylation pathways to promote endometriosis susceptibility.iScience · 2026Article
- A Three-Decade Overview of Cadmium and Lead in Placentas of Postpartum Women: A Review of Evidence from Croatia (1990s-2019).Life (Basel, Switzerland) · 2026Article
- Serum heavy metal levels from tobacco smoke and Buerger's disease.Scientific reports · 2025Article
- Essential and Non-Essential Metals and Metalloids and Their Role in Atherosclerosis.Cardiovascular toxicology · 2025Review
- Early Zinc Supplementation Enhances Epididymal Sperm Glycosylation, Endocrine Activity, and Antioxidant Activity in Rats Exposed to Cadmium.International journal of molecular sciences · 2025Article
- The effect of consuming bread contaminated with heavy metals on cardiovascular disease and calculating its risk assessment.Scientific reports · 2025Article
- Cerebrovascular accidents association between serum trace elements and toxic metals level, a case-control study.PloS one · 2025Article
- Metals, cardiovascular risk, and the interplay with oxidative stress: a mini-review.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025Review
- Investigation of the relationship between lead exposure in heavy metals mixtures and the prevalence of stroke: a cross-sectional study.BMC public health · 2024Article
- Association between urinary cobalt exposure and kidney stones in U.S. adult population: results from the National Health and Nutrition Examination Survey.Renal failure · 2024Article
- Urinary Metal Levels and Coronary Artery Calcification: Longitudinal Evidence in the Multi-Ethnic Study of Atherosclerosis.Journal of the American College of Cardiology · 2024Article
- Translational toxicology of metal(loid) species: linking their bioinorganic chemistry in the bloodstream to organ damage onset.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024Review
- Exposure to Lead in Drinking Water Causes Cognitive Impairment via an Alzheimer's Disease Gene-Dependent Mechanism in Adult Mice.Journal of Alzheimer's disease : JAD · 2024Article
- Potential pathogenic roles of ferroptosis and cuproptosis in cadmium-induced or exacerbated cardiovascular complications in individuals with diabetes.Frontiers in endocrinology · 2024Review
49 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Vascular system function involves complex interactions among the vascular endothelium, smooth muscle, the immune system, and the nervous system. The toxic metals cadmium (Cd), arsenic (As), and lead (Pb) can target the vascular system in a variety of ways, ranging from hemorrhagic injury to subtle pathogenic remodeling and metabolic changes. Acute Cd exposure results in hemorrhagic injury to the testis, although some strains of animals are resistant to this effect. A comparison of Cd-sensitive with Cd-resistant mouse strains showed that expression of the Slc39a8 gene, encoding the ZIP8 transporter, in the testis vasculature endothelium is responsible for this difference. Endogenously, ZIP8 is a Mn(2+)/HCO(3)(-)symporter that may also contribute to Cd damage in the kidney. Chronic Cd exposure is associated with various cardiovascular disorders such as hypertension and cardiomyopathy and it is reported to have both carcinogenic and anticarcinogenic activities. At noncytotoxic concentrations of 10-100nM, Cd can inhibit chemotaxis and tube formation of vascular endothelial cells. These angiostatic effects may be mediated through disruption of vascular endothelial cadherin, a Ca(2+)-dependent cell adhesion molecule. With regard to As, ingestion of water containing disease-promoting concentrations of As promotes capillarization of the liver sinusoidal endothelium. Because capillarization is a hallmark precursor for liver fibrosis and contributes to an imbalance of lipid metabolism, this As effect on hepatic endothelial cells may be a pathogenic mechanism underlying As-related vascular diseases. With regard to Pb, perinatal exposure may cause sustained elevations in adult blood pressure, and genetically susceptible animals may show enhanced sensitivity to this effect. Taken together, these data indicate that the vascular system is a critical target of metal toxicity and that actions of metals on the vascular system may play important roles in mediating the pathophysiologic effects of metals in specific target organs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.