ArticleThe Journal of physiology2007
Pathway-specific use-dependent dynamics of excitatory synaptic transmission in rat intracortical circuits.
Article in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Auditory Corticofugal Neurons Transmit Auditory and Non-auditory Information During Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
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- Structural Properties of Synaptic Transmission and Temporal Dynamics at Excitatory Layer 5B Synapses in the Adult Rat Somatosensory Cortex.Frontiers in synaptic neuroscience · 2018Article
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- Dendritic Excitability and Gain Control in Recurrent Cortical Microcircuits.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
- Cell-specific activity-dependent fractionation of layer 2/3→5B excitatory signaling in mouse auditory cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Glutamate-bound NMDARs arising from in vivo-like network activity extend spatio-temporal integration in a L5 cortical pyramidal cell model.PLoS computational biology · 2014Article
- Diverse thalamocortical short-term plasticity elicited by ongoing stimulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Article
- Imbalance between excitation and inhibition in the somatosensory cortex produces postadaptation facilitation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Hierarchical connectivity and connection-specific dynamics in the corticospinal-corticostriatal microcircuit in mouse motor cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Specificity of synaptic connectivity between layer 1 inhibitory interneurons and layer 2/3 pyramidal neurons in the rat neocortex.Cerebral cortex (New York, N.Y. : 1991) · 2011Article
- Postnatal development of intrinsic and synaptic properties transforms signaling in the layer 5 excitatory neural network of the visual cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Atypical properties of release and short-term depression at a specialized nicotinic synapse in the Mauthner cell network.The Journal of experimental biology · 2011Article
- Neuronal arithmetic.Nature reviews. Neuroscience · 2010Review
- Conditional bursting enhances resonant firing in neocortical layer 2-3 pyramidal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
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2 authors.
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Abstract
Information processing in neuronal networks is determined by the use-dependent dynamics of synaptic transmission. Here we characterize the dynamic properties of excitatory synaptic transmission in two major intracortical pathways that target the output neurons of the neocortex, by recording unitary EPSPs from layer 5 pyramidal neurons evoked in response to action potential trains of increasing complexity in presynaptic layer 2/3 or layer 5 pyramidal neurons. We find that layer 2/3 to layer 5 synaptic transmission is dominated by frequency-dependent depression when generated at fixed frequencies of > 10 Hz. Synaptic depression evolved on a spike-by-spike basis in response to action potential trains that possessed a broad range of interspike intervals, but a low mean frequency (10 Hz). Layer 2/3 to layer 2/3 and layer 2/3 to layer 5 synapses were incapable of sustained release during prolonged, complex trains of presynaptic action potential firing (mean frequency, 48 Hz). By contrast, layer 5 to layer 5 synapses operated effectively across a wide range of frequencies, exhibiting increased efficacy at frequencies > 10 Hz. Furthermore, layer 5 to layer 5 synapses sustained release throughout the duration of prolonged, complex spike trains. The use-dependent properties of synaptic transmission could be modulated by pharmacologically changing the probability of release and by induction of long-term depression. The dynamic properties of intracortical excitatory synapses are therefore pathway-specific. We suggest that the synaptic output of layer 5 pyramidal neurons is ideally suited to control the neocortical network across a wide range of frequencies and for sustained periods of time, a behaviour that helps to explain the pivotal role played by layer 5 neurons in the genesis of periods of network 'up' states and epileptiform activity in the neocortex.
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