Trial reportThe Journal of physiology2007
Endogenous nitric oxide attenuates neutrally mediated cutaneous vasoconstriction.
Trial report in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Meta-analysis of heat-induced changes in cardiac function from over 400 laboratory-based heat exposure studies.Nature communications · 2025Pooled it
- Oral sapropterin augments reflex vasoconstriction in aged human skin through noradrenergic mechanisms.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Trial
- Intradermal administration of ATP does not mitigate tyramine-stimulated vasoconstriction in human skin.American journal of physiology. Regulatory, integrative and comparative physiology · 2010Trial
- Cerebrovascular regulation during heat stress.Experimental physiology · 2026Review
- Impact of environmental stressors on tolerance to hemorrhage in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Do nitric oxide synthase and cyclooxygenase contribute to sweating response during passive heating in endurance-trained athletes?Physiological reports · 2017Article
- Individual variations in nitric oxide synthase-dependent sweating in young and older males during exercise in the heat: role of aerobic power.Physiological reports · 2017Article
- Mechanisms of orthostatic intolerance during heat stress.Autonomic neuroscience : basic & clinical · 2016Review
- Cutaneous vascular and sweating responses to intradermal administration of ATP: a role for nitric oxide synthase and cyclooxygenase?The Journal of physiology · 2015Article
- Human cardiovascular responses to passive heat stress.Comprehensive Physiology · 2015Review
- Active and passive heat stress similarly compromise tolerance to a simulated hemorrhagic challenge.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Forehead versus forearm skin vascular responses at presyncope in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Blunted cutaneous vasoconstriction and increased frequency of presyncope during an orthostatic challenge under moderate heat stress in the morning.European journal of applied physiology · 2014Article
- Blood pressure regulation III: what happens when one system must serve two masters: temperature and pressure regulation?European journal of applied physiology · 2014Review
- Elevated local skin temperature impairs cutaneous vasoconstrictor responses to a simulated haemorrhagic challenge while heat stressed.Experimental physiology · 2013Article
- Effect of heat stress on cardiac output and systemic vascular conductance during simulated hemorrhage to presyncope in young men.American journal of physiology. Heart and circulatory physiology · 2012Article
- Aging and exercise training reduce testes microvascular PO2 and alter vasoconstrictor responsiveness in testicular arterioles.American journal of physiology. Regulatory, integrative and comparative physiology · 2011Article
- Mechanisms of cutaneous vasodilation during the postmenopausal hot flash.Menopause (New York, N.Y.) · 2011Article
- Tetrahydrobiopterin does not affect end-organ responsiveness to norepinephrine-mediated vasoconstriction in aged skin.American journal of physiology. Regulatory, integrative and comparative physiology · 2010Article
- Insufficient cutaneous vasoconstriction leading up to and during syncopal symptoms in the heat stressed human.American journal of physiology. Heart and circulatory physiology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Cutaneous vasoconstrictor responsiveness may be impaired by substance(s) directly or indirectly responsible for cutaneous active vasodilatation. In this study, we tested the hypothesis that endogenous nitric oxide (NO) attenuates the reduction in cutaneous vascular conductance (CVC) during an orthostatic challenge combined with whole-body heating, as well as during whole-body cooling. In protocol 1, healthy subjects were pretreated with an intradermal injection of botulinum toxin A (BTX) to block the release of neurotransmitters from nerves responsible for cutaneous active vasodilatation. On the experimental day, a microdialysis probe was placed at the BTX-treated site as well as at two adjacent untreated sites. NG-nitro-l-arginine methyl ester (L-NAME, 10 mm) was perfused through the probe placed at the BTX-treated site and at one untreated site. After confirmation of the absence of cutaneous vasodilatation at the BTX site during whole-body heating, adenosine was infused through the microdialysis probe at this site to increase skin blood flow to a level similar to that at the untreated site. Subsequently, 30 and 40 mmHg lower-body negative pressures (LBNPs) were applied. The reduction in CVC to LBNP was greatest at the BTX-treated site (15.0 +/- 2.4% of the maximum level (% max)), followed by the L-NAME-treated site (11.3 +/- 2.6% max), and then the untreated site (3.8 +/- 3.0% max; P < 0.05 for all comparisons). In protocol 2, two microdialysis membranes were inserted in the dermal space of one forearm. Adenosine alone was infused at one site while the other site received adenosine and L-NAME. The reduction in CVC in response to whole-body cooling was significantly greater at the L-NAME-treated site than at the adjacent adenosine alone site. These results suggest that endogenous NO is capable of attenuating cutaneous vasoconstrictor responsiveness.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.