ReviewThe Journal of physiology2008
Active properties of motoneurone dendrites: diffuse descending neuromodulation, focused local inhibition.
Review in The Journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
74 citing papers in PubMed.
- 5-HTThe Journal of physiology · 2025Trial
- Ischemic conditioning increases strength and volitional activation of paretic muscle in chronic stroke: a pilot study.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Trial
- Serotonin affects movement gain control in the spinal cord.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Trial
- The relationship between the flexion synergy and stretch reflexes in individuals with chronic hemiparetic stroke.IEEE ... International Conference on Rehabilitation Robotics : [proceedings] · 2011Trial
- Motor unit discharge rates of the anconeus muscle during high-velocity elbow extensions.Experimental brain research · 2011Trial
- Muscle cramp susceptibility is associated with muscle-specific modulation of human motoneuron discharge patterns.Experimental physiology · 2026Article
- Estimation of persistent inward currents contribution to inspiratory motoneuron firing in humans.The Journal of physiology · 2026Article
- Isometric handgrip contraction increases tibialis anterior intrinsic motoneuron excitability in a dose-dependent manner.Experimental physiology · 2026Article
- Difference in the Motor Unit Firing Behavior During Submaximal Isometric Ramp Contraction Between Healthy Children Aged 6-12 Years and Young Adults.Muscle & nerve · 2026Article
- Intrinsic properties of spinal motoneurons degrade ankle torque control in humans.The Journal of physiology · 2025Article
- Article
- Motoneuron persistent inward current contribution to increased torque responses to wide-pulse high-frequency neuromuscular electrical stimulation.European journal of applied physiology · 2024Article
- Voluntary co-contraction of ankle muscles alters motor unit discharge characteristics and reduces estimates of persistent inward currents.The Journal of physiology · 2024Article
- Influence of visual feedback and cognitive challenge on the age-related changes in force steadiness.Experimental brain research · 2024Article
- Voluntary co-contraction of ankle muscles alters motor unit discharge characteristics and reduces estimates of persistent inward currents.bioRxiv : the preprint server for biology · 2024Article
- Estimates of persistent inward currents in lower limb motoneurons are larger in females than in males.Journal of neurophysiology · 2023Article
- Facilitation-inhibition control of motor neuronal persistent inward currents in young and older adults.The Journal of physiology · 2022Article
- Pupil diameter tracked during motor adaptation in humans.Journal of neurophysiology · 2022Article
- Voluntary activation of muscle in humans: does serotonergic neuromodulation matter?The Journal of physiology · 2022Review
- 5-HTThe European journal of neuroscience · 2022Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The dendrites of spinal motoneurones are highly active, generating a strong persistent inward current (PIC) that has an enormous impact on processing of synaptic input. The PIC is subject to regulation by descending neuromodulatory systems releasing the monoamines serotonin and noradrenaline. At high monoaminergic drive levels, the PIC dominates synaptic integration, generating an intrinsic dendritic current that is as much as 5-fold larger than the current entering via synapses. Without the PIC, motoneurone excitability is very low. Presumably, this descending control of the synaptic integration via the PIC is used to adjust the excitability (gain) of motoneurones for different motor tasks. A problem with this gain control is that monoaminergic input to the cord is very diffuse, affecting many motor pools simultaneously, probably including both agonists and antagonists. The PIC is, however, exquisitely sensitive to the reciprocal inhibition mediated by length sensitive muscle spindle Ia afferents and Ia interneurones. Reciprocal inhibition is tightly focused, shared only between strict mechanical antagonists, and thus can act to 'sculpt' specific movement patterns out of a background of diffuse neuromodulation. Thus it is likely that motoneurone gain is set by the interaction between diffuse descending neuromodulation and specific and focused local synaptic inhibitory circuits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.