ArticleBMC microbiology2007
Characterization of Campylobacter phages including analysis of host range by selected Campylobacter Penner serotypes.
Article in BMC microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Statistical structure of host-phage interactions.Proceedings of the National Academy of Sciences of the United States of America · 2011Pooled it
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- Investigating bacteriophages as a novel multiple-hurdle measure against Campylobacter: field trials in commercial broiler plants.Scientific reports · 2024Article
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- Campylobacter spp. and bacteriophages from broiler chickens: Characterization of antibiotic susceptibility profiles and lytic bacteriophages.MicrobiologyOpen · 2019Article
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- Phase Variable Expression of a Single Phage Receptor inFrontiers in microbiology · 2018Article
- Current and Potential Treatments for ReducingFrontiers in microbiology · 2017Review
- A multiplex real-time PCR for the detection and differentiation of Campylobacter phages.PloS one · 2017Article
- Campylobacter group II phage CP21 is the prototype of a new subgroup revealing a distinct modular genome organization and host specificity.BMC genomics · 2015Article
- Primary isolation strain determines both phage type and receptors recognised by Campylobacter jejuni bacteriophages.PloS one · 2015Article
- Campylobacter jejuni motility is required for infection of the flagellotropic bacteriophage F341.Applied and environmental microbiology · 2014Article
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- Reduction of Campylobacter jejuni in broiler chicken by successive application of group II and group III phages.PloS one · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe predominant food borne pathogen in the western world today is Campylobacter. Campylobacter specific bacteriophages (phages) have been proposed as an alternative agent for reducing the burden of Campylobacter in broilers. One concern in relation to phage biocontrol is the narrow host range often displayed by phages. To identify the potential of phages as a Campylobacter reducing agent we needed to determine their infectivity on a panel of isolates representing the Campylobacter strains found in broilers as well as humans.
resultsIn this study, Campylobacter phages were isolated from the intestines of broilers and ducks and from abattoir sewage. Twelve phages were investigated to determine their ability to infect the Campylobacter Penner serotypes commonly present in Danish poultry and patients with campylobacteriosis. A total of 89% of the Campylobacter jejuni strains and 14% of the Campylobacter coli strains could be infected by at least one of the bacteriophages. The majority of the phages infected the most common serotypes in Danish broilers (O:1,44; O:2; O:4-complex), but showed limited ability to infect 21 of the less frequent Campylobacter serotypes. Pulse field gel electrophoresis (PFGE) and restriction endonuclease analysis (REA) were used to characterize the phage genomes. Three categories of bacteriophages were observed. I: a genome size of approximately 194 kb and refractory to digestion with HhaI; II: a genome size of approximately 140 kb and digestible by HhaI; and III: a genome size undeterminable in PFGE. The categorization of the phages correlated with the host range patterns displayed by the phages. Six phages were subjected to transmission electron microscopy (TEM). They all belonged to the family of Myoviridae.
conclusionWe have characterized and identified the host range of 12 Danish Campylobacter phages. Due to their ability to infect the majority of the common serotypes in Denmark we suggest the phages can become an effective agent in the effort to reduce the incidence of campylobacteriosis in Denmark. This study provides the basis for future experiments in Campylobacter phages and knowledge for the selection of Campylobacter phages for biocontrol in broilers.
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