ArticleCritical care (London, England)2007
Improved survival of children with sepsis and purpura: effects of age, gender, and era.
Article in Critical care (London, England), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- Criteria for Pediatric Sepsis-A Systematic Review and Meta-Analysis by the Pediatric Sepsis Definition Taskforce.Critical care medicine · 2022Pooled it
- Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012.Intensive care medicine · 2013Guideline
- Clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock: 2007 update from the American College of Critical Care Medicine.Critical care medicine · 2009Guideline
- Long noncoding RNA and messenger RNA abnormalities in pediatric sepsis: a preliminary study.BMC medical genomics · 2020Trial
- Base deficit and alactic base excess are promising early biological markers in pediatric sepsis.BMC pediatrics · 2026Article
- Factors associated with death in children with purpura fulminans: a French national prospective cohort study.Critical care (London, England) · 2021Article
- Transcriptomic markers in pediatric septic shock prognosis: an integrative analysis of gene expression profiles.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2021Article
- Clinical spectrum and short-term outcome of adult patients with purpura fulminans: a French multicenter retrospective cohort study.Intensive care medicine · 2018Observational
- Differences in IgG Fc Glycosylation Are Associated with Outcome of Pediatric Meningococcal Sepsis.mBio · 2018Article
- Identification of potential transcriptomic markers in developing pediatric sepsis: a weighted gene co-expression network analysis and a case-control validation study.Journal of translational medicine · 2017Article
- [Sepsis-associated Purpura Fulminans International Registry--Europe (SAPFIRE)].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2014Article
- Management of children with sepsis and septic shock: a survey among pediatric intensivists of the Réseau Mère-Enfant de la Francophonie.Annals of intensive care · 2013Article
- Incidence and risk factors for mortality in paediatric severe sepsis: results from the national paediatric intensive care registry in Japan.Intensive care medicine · 2012Article
- Human protein C concentrate in the treatment of purpura fulminans: a retrospective analysis of safety and outcome in 94 pediatric patients.Critical care (London, England) · 2010Article
- Surviving pediatric intensive care: physical outcome after 3 months.Intensive care medicine · 2008Article
- Outcome research in meningococcal septic shock.Critical care (London, England) · 2008Article
- Improvements in the outcome of children with meningococcal disease.Critical care (London, England) · 2007Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo gain insight into factors that might affect results of future case-control studies, we performed an analysis of children with sepsis and purpura admitted to the paediatric intensive care unit (PICU) of Erasmus MC-Sophia Children's Hospital (Rotterdam, The Netherlands).
methodsBetween 1988 and 2006, all 287 children consecutively admitted with sepsis and purpura were included in various sepsis studies. Data regarding age, gender, ethnicity, serogroup of Neisseria meningitidis, severity, therapy, and survival were collected prospectively. These data were pooled into one database and analyzed retrospectively.
resultsThe case fatality rate (CFR) from sepsis and purpura was 15.7%. During the study period, survival improved significantly. Younger age was significantly associated with more severe disease and a higher CFR. Children under the median age of 3.0 years had an increased risk of case fatality (odds ratio 4.3, 95% confidence interval 2.1 to 9.2; p < 0.001). Gender was not associated with CFR. However, males did have higher Paediatric Risk of Mortality scores, fewer PICU-free days, and more presence of shock. The course of sepsis and purpura was not related to ethnic origin. A causative organism was isolated in 84.3% of cases. N. meningitidis was the major organism (97.5%). Although N. meningitidis serogroup B was observed more often in younger children, serogroups were not associated with severity or survival. During the study period, the use of inotropic agents and corticosteroids changed substantially (less dopamine and more dobutamine, norepinephrine, and corticosteroids).
conclusionAge and gender are determinants of severity of paediatric sepsis and purpura. Survival rates have improved during the last two decades.
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