SynthesisThe Cochrane database of systematic reviews2007
Protein restriction for children with chronic renal failure.
Synthesis in The Cochrane database of systematic reviews, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Energy and protein requirements for children with CKD stages 2-5 and on dialysis-clinical practice recommendations from the Pediatric Renal Nutrition Taskforce.Pediatric nephrology (Berlin, Germany) · 2020Guideline
- Evidence-based practice guideline for the treatment of CKD.Clinical and experimental nephrology · 2009Guideline
- Plasma Metabolomics of Dietary Intake of Protein-Rich Foods and Kidney Disease Progression in Children.Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation · 2024Article
- Eating Disorders in Youth with Chronic Health Conditions: Clinical Strategies for Early Recognition and Prevention.Nutrients · 2023Review
- Review
- Childhood risk factors for adulthood chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2021Review
- Clinical Management of Children with a Congenital Solitary Functioning Kidney: Overview and Recommendations.European urology open science · 2021Review
- Chronic Kidney Disease: Treatment of Comorbidities I: (Nutrition, Growth, Neurocognitive Function, and Mineral Bone Disease).Current treatment options in pediatrics · 2019Article
- Review
- Common Elements in Rare Kidney Diseases: Conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.Kidney international · 2017Article
- Article
- Protein intake in infancy and kidney size and function at the age of 6 years: The Generation R Study.Pediatric nephrology (Berlin, Germany) · 2015Article
- Autosomal dominant polycystic kidney disease in children.Current opinion in pediatrics · 2015Review
- Chronic kidney disease in adolescent and adult patients with phenylketonuria.Journal of inherited metabolic disease · 2013Article
- Chapter 5: Referral to specialists and models of care.Kidney international supplements · 2013Article
- Chapter 3: Management of progression and complications of CKD.Kidney international supplements · 2013Article
- Educational paper: Progression in chronic kidney disease and prevention strategies.European journal of pediatrics · 2012Review
- Protective Effect of Heat-processed Ginseng (Sun Ginseng) in the Adenine-induced Renal Failure Rats.Journal of ginseng research · 2012Article
- Nutrition and growth in children with chronic kidney disease.Nature reviews. Nephrology · 2011Review
- Therapeutic strategies to slow chronic kidney disease progression.Pediatric nephrology (Berlin, Germany) · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProtein restriction has been prescribed for some time for patients with chronic kidney disease (CKD). The effect of a low protein diet on delaying the progression to end-stage kidney disease (ESKD) in children and its impact on growth and nutrition remains unresolved.
objectivesTo determine the efficacy of protein restricted diet in delaying the start of maintenance dialysis and maintaining nutrition in children. SEARCH STRATEGY: Cochrane Renal group trials register, the Cochrane Central register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, reference lists of nephrology textbooks, review articles and relevant trials. SELECTION CRITERIA: Randomised control trials (RCTs) comparing un-restricted protein diet versus a protein restricted diet (to safe amounts recommended by WHO), with follow-up period of at least six months were included. DATA COLLECTION AND ANALYSIS: Two authors independently selected studies. Statistical analysis were performed using the random effects model. For dichotomous outcome results are expressed as relative risk (RR) with 95% confidence intervals (CI). Where continuous scales of measurement are used to assess the effects of treatment, the mean difference (WMD) was used. MAIN
resultsTwo studies (250 children) were identified, 124 received a protein restricted diet and 126 a control diet. No significant differences was found in the number of renal deaths (RR 1.12, 95% CI 0.54 to 2.33), progression of kidney disease (creatinine clearance at two years: WMD 1.47, 95% CI -1.19 to 4.14) or growth (weight - WMD -0.13, 95% CI -1.10 to 0.84; height - WMD -1.99, 95% CI -4.84 to 0.86). AUTHORS'
conclusionsReducing protein intake does not appear to have significant impact in delaying the progression to ESKD in children.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.