SynthesisThe Cochrane database of systematic reviews2007
Fish oil for induction of remission in ulcerative colitis.
Synthesis in The Cochrane database of systematic reviews, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Evidence-based clinical practice guidelines for inflammatory bowel disease.Journal of gastroenterology · 2018Guideline
- Reducing Disease Activity of Inflammatory Bowel Disease by Consumption of Plant-Based Foods and Nutrients.Frontiers in nutrition · 2021Review
- Fish, Shellfish, and Children's Health: An Assessment of Benefits, Risks, and Sustainability.Pediatrics · 2019Article
- The Imbalance between n-6/n-3 Polyunsaturated Fatty Acids and Inflammatory Bowel Disease: A Comprehensive Review and Future Therapeutic Perspectives.International journal of molecular sciences · 2017Review
- Biosynthesis of proresolving lipid mediators by vascular cells and tissues.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Integrative Medicine for Gastrointestinal Disease.Primary care · 2017Review
- A Review of Recruitment, Adherence and Drop-Out Rates in Omega-3 Polyunsaturated Fatty Acid Supplementation Trials in Children and Adolescents.Nutrients · 2017Review
- Nutritional concerns in pediatric inflammatory bowel disease.Korean journal of pediatrics · 2016Review
- Effects of increase in fish oil intake on intestinal eicosanoids and inflammation in a mouse model of colitis.Lipids in health and disease · 2013Article
- Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology?British journal of clinical pharmacology · 2013Article
- Impact of environmental and dietary factors on the course of inflammatory bowel disease.World journal of gastroenterology · 2012Review
- Nutritional management of adults with inflammatory bowel disease: practical lessons from the available evidence.Frontline gastroenterology · 2012Review
- Review on efficacy and health services research studies of complementary and alternative medicine in inflammatory bowel disease.Chinese journal of integrative medicine · 2011Review
- Vitamin D and gastrointestinal diseases: inflammatory bowel disease and colorectal cancer.Therapeutic advances in gastroenterology · 2011Article
- Lyprinol-is it a useful anti-inflammatory agent?Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Dietary docosahexaenoic and eicosapentaenoic acid: emerging mediators of inflammation.Prostaglandins, leukotrienes, and essential fatty acidsReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFish oil supplements, which are rich in n-3 fatty acids, may reduce inflammation, decrease the need for anti-inflammatory drugs, and promote normal weight gain in people with ulcerative colitis.
objectivesThis review evaluates the efficacy of fish oil for induction of remission in ulcerative colitis using all available randomised controlled trials. SEARCH STRATEGY: The Cochrane Central Register of Controlled Trials (CENTRAL), PUBMED, EMBASE, CINAHL, the database of ongoing trials and the reference lists of all publications of included or excluded trials were searched. SELECTION CRITERIA: Randomised controlled trials and quasi-randomised controlled trials with active ulcerative colitis patients who were treated with fish oil. DATA COLLECTION AND ANALYSIS: The reviewers performed study selection, assessment of methodological quality by using different approaches: including Cochrane assessment of allocation concealment and Jadad quality assessment score. Data extraction forms were used by the two reviewers to extract the data independently. Authors were contacted for additional information. MAIN
resultsSix studies were included. Three were of cross-over design and three were of parallel design. No data were pooled for analysis due to differences in outcomes and methodology among the included studies. One small study shows a positive benefit for induction of remission (RR 19.00; 95% CI 1.27 to 284.24). Some of the other included studies show some positive benefits for secondary outcomes. However, these results need to be interpreted with caution due to small study size and poor study quality. AUTHORS'
conclusionsThe current data does not allow for a definitive conclusion regarding the efficacy of fish oil. There is no adequate information to make recommendations for clinical practice. More research is required.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.