ArticleJournal of materials science. Materials in medicine2008
The effect of adsorbed vitamin D and K to hydroxyapatite on ALP activity of MC3T3-E1 cell.
Article in Journal of materials science. Materials in medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Bioactive Materials for Bone Regeneration: Biomolecules and Delivery Systems.ACS biomaterials science & engineering · 2023Review
- Low serum 25-hydroxyvitamin D levels are associated with liver injury markers in the US adult population.Public health nutrition · 2020Article
- Cross talk between redox signalling and metabolic activity of osteoblasts and fibroblasts in the presence of hydroxyapatite-based biomaterials influences bone regeneration.Journal of applied biomedicine · 2019Article
- Article
- Synthesis of Hydroxyapatite, β-Tricalcium Phosphate and Biphasic Calcium Phosphate Particles to Act as Local Delivery Carriers of Curcumin: Loading, Release and In Vitro Studies.Materials (Basel, Switzerland) · 2018Article
- Human Amnion-Derived Mesenchymal Stem Cells Protect Human Bone Marrow Mesenchymal Stem Cells against Oxidative Stress-Mediated Dysfunction via ERK1/2 MAPK Signaling.Molecules and cells · 2016Article
- Human Amnion-Derived Mesenchymal Stem Cells Promote Osteogenic Differentiation in Human Bone Marrow Mesenchymal Stem Cells by Influencing the ERK1/2 Signaling Pathway.Stem cells international · 2016Article
- Panax notoginseng stimulates alkaline phosphatase activity, collagen synthesis, and mineralization in osteoblastic MC3T3-E1 cells.In vitro cellular & developmental biology. Animal · 2015Article
- Human amnion mesenchymal stem cells promote proliferation and osteogenic differentiation in human bone marrow mesenchymal stem cells.Journal of molecular histology · 2015Article
- PAPSS2 promotes alkaline phosphates activity and mineralization of osteoblastic MC3T3-E1 cells by crosstalk and Smads signal pathways.PloS one · 2012Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study describes the adsorptive property of vitamins on HA and the effect of the HA adsorbed vitamin on the alkaline phosphatase (ALP) activity for effective use as a bone graft substitute. The vitamins used were calciferol (D3), menaquirone (K2) and 25-hydroxycholecalciferol (25(OH)D3). These vitamins were adsorbed on HA at 4, 10, 20, 37 and 50 degrees C. The adsorption amount was constant below 20 degrees C, and decreased as the incubation temperature increased over 20 degrees C. The order of the adsorption amount was: 25(OH)D3 > K2 > D3. The HA adsorbed vitamins (HA/D3, HA/25(OH)D3 and HA/K2) were suspended in physiological saline for 48 h for the release test. The release ratio of all vitamins increased with incubation time. The order of the release ratio was: 25(OH)D3 > K2 > D3, which was proportional to that of the adsorption amount. The ALP activity of MC3T3-E1 osteoblast-like cells on HA, HA/D3, HA/25(OH)D3 and HA/K2 was also investigated. The ALP activity was higher on HA/25(OH)D3 than on any other samples. However, HA/K2 and HA/D3 showed similar ALP activity to HA.
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Registered trials
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