ReviewChromosoma2008
Inositol polyphosphates: a new frontier for regulating gene expression.
Review in Chromosoma, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 98 citations in OpenAlex.
- Proteome-wide quantification of inositol pyrophosphate-protein interactions.Nature communications · 2026Article
- Targeting IPNature communications · 2026Article
- Protein pyrophosphorylation by inositol phosphates: a novel post-translational modification in plants?Frontiers in plant science · 2024Review
- Defining the lipidome of Arabidopsis leaf mitochondria: Specific lipid complement and biosynthesis capacity.Plant physiology · 2023Article
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- Review
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- A synthetic biological approach to reconstitution of inositide signaling pathways in bacteria.Advances in biological regulation · 2019Article
- A synthetic cyclitol-nucleoside conjugate polyphosphate is a highly potent second messenger mimic.Chemical science · 2019Article
- Fungal Kinases With a Sweet Tooth: Pleiotropic Roles of Their Phosphorylated Inositol Sugar Products in the Pathogenicity ofFrontiers in cellular and infection microbiology · 2019Review
- Phospholipids and inositol phosphates linked to the epigenome.Histochemistry and cell biology · 2018Review
- Phytase overexpression in Arabidopsis improves plant growth under osmotic stress and in combination with phosphate deficiency.Scientific reports · 2018Article
- Yeast phospholipase C is required for stability of casein kinase I Yck2p and expression of hexose transporters.FEMS microbiology letters · 2017Article
- Physiological and transcriptome analysis of heteromorphic leaves and hydrophilic roots in response to soil drying in desert Populus euphratica.Scientific reports · 2017Article
- Role of the Inositol Polyphosphate Multikinase Ipk2 in Regulation of Hyphal Development, Calcium Signaling and Secretion in Candida albicans.Mycopathologia · 2017Article
- Inositol Polyphosphate Kinases, Fungal Virulence and Drug Discovery.Journal of fungi (Basel, Switzerland) · 2016Review
- Identification of a major IP5 kinase in Cryptococcus neoformans confirms that PP-IP5/IP7, not IP6, is essential for virulence.Scientific reports · 2016Article
- The "Other" Inositols and Their Phosphates: Synthesis, Biology, and Medicine (with Recent Advances in myo-Inositol Chemistry).Angewandte Chemie (International ed. in English) · 2016Review
- Transcriptomic Profiling Analysis of Arabidopsis thaliana Treated with Exogenous Myo-Inositol.PloS one · 2016Article
- Seed Biofortification and Phytic Acid Reduction: A Conflict of Interest for the Plant?Plants (Basel, Switzerland) · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Highly phosphorylated, soluble inositides are an emerging family of potential eukaryotic second messengers. The mechanisms for generating an outstanding diversity of mono- and pyrophosphorylated inositides have been recently elucidated and require a series of conserved lipases, kinases, and phosphatases. With several of the inositol kinases and the phospholipase C having access to the nucleus, roles for inositides in nuclear functions have been suggested. In support of this hypothesis, multiple studies have revealed the protein machines that are modulated by these inositides and found specific roles in nuclear physiology. In this paper, we review a novel paradigm for regulating gene expression at distinct steps by different inositide isomers. We discuss discoveries showing inositol polyphosphate regulation of gene expression at the level of transcription, chromatin remodeling, messenger ribonucleic acid (mRNA) editing, and mRNA export. Recent structural studies of inositol polyphosphate-binding proteins suggest the inositides modulate protein function as essential structural cofactors, triggers for allosteric or induced fit structural changes, and direct antagonistic competitors for other inositide ligands. We propose that the cell orchestrates the localized production of soluble inositol polyphosphates and inositol pyrophosphates to direct decisive and rapid signaling events. These insights also illustrate how extracellular stimuli might faithfully trigger the correct synchrony between gene expression steps and coordinate nuclear responses to changes in cellular environments.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.