ArticleNature2007
The equilibria that allow bacterial persistence in human hosts.
Article in Nature, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
113 citing papers in PubMed.
- Similar intraoperative microbiomes inFrontiers in cellular and infection microbiology · 2026Article
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- A Comprehensive Review of Antibiotic Resistance in the Oral Microbiota: Mechanisms, Drivers, and Emerging Therapeutic Strategies.Antibiotics (Basel, Switzerland) · 2025Review
- Influence of the Origin, Feeding Status, andBiology · 2025Article
- Isolation, Characterization, and Preliminary Application of Staphylococcal Bacteriophages in SichuanMicroorganisms · 2025Article
- Insights into Autophagy in Microbiome Therapeutic Approaches for Drug-Resistant Tuberculosis.Cells · 2025Review
- Risk Factors, Pathogenesis, Prevention and Clinical Features of Cardiovascular Implantable Electronic Device (CIED) Infections.Journal of community hospital internal medicine perspectives · 2025Review
- Preclinical and clinical evaluation of ECM bioenvelopes for preventing CIED pocket complications.Frontiers in cardiovascular medicine · 2025Review
- Estradiol metabolism by gut microbiota in women's depression pathogenesis: inspiration from nature.Frontiers in psychiatry · 2025Review
- The microbiome in endometrial cancer: vaginal milieu matters.Frontiers in medicine · 2025Article
- Single missense mutations in Vi capsule synthesis genes confer hypervirulence to Salmonella Typhi.Nature communications · 2024Article
- Single cell genomics based insights into the impact of cell-type specific microbial internalization on disease severity.Frontiers in immunology · 2024Review
- Inter-kingdom communication and the sympoietic way of life.Frontiers in cell and developmental biology · 2024Article
- Article
- ESAT-6 a Major Virulence Factor ofBiomolecules · 2023Review
- The Evolution of Diagnostic Techniques in the Paleopathology of Tuberculosis: A Scoping Review.Pathogens & immunity · 2023Article
- The pathogenic mechanism of Mycobacterium tuberculosis: implication for new drug development.Molecular biomedicine · 2022Review
- Mycobacterium tuberculosis senses host Interferon-γ via the membrane protein MmpL10.Communications biology · 2022Article
- Article
- Computational approach to modeling microbiome landscapes associated with chronic human disease progression.PLoS computational biology · 2022Article
53 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We propose that microbes that have developed persistent relationships with human hosts have evolved cross-signalling mechanisms that permit homeostasis that conforms to Nash equilibria and, more specifically, to evolutionarily stable strategies. This implies that a group of highly diverse organisms has evolved within the changing contexts of variation in effective human population size and lifespan, shaping the equilibria achieved, and creating relationships resembling climax communities. We propose that such ecosystems contain nested communities in which equilibrium at one level contributes to homeostasis at another. The model can aid prediction of equilibrium states in the context of further change: widespread immunodeficiency, changing population densities, or extinctions.
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17943121What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.