Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
How progesterone impairs memory for biologically salient stimuli in healthy young women.
Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 135 citations in OpenAlex.
- Effects of separate and combined estradiol and progesterone administration on fear extinction in healthy pre-menopausal women.Translational psychiatry · 2024Trial
- The neurosteroids allopregnanolone and dehydroepiandrosterone modulate resting-state amygdala connectivity.Human brain mapping · 2014Trial
- Allopregnanolone elevations following pregnenolone administration are associated with enhanced activation of emotion regulation neurocircuits.Biological psychiatry · 2013Trial
- Progesterone improves cognitive performance and attenuates smoking urges in abstinent smokers.Psychoneuroendocrinology · 2011Trial
- Facial emotion recognition and amygdala activation are associated with menstrual cycle phase.Psychoneuroendocrinology · 2008Trial
- Allopregnanolone impairs episodic memory in healthy women.Psychopharmacology · 2008Trial
- Plasma Allopregnanolone and Sex Hormone Responses to Stress Induction: Contributors to the Formation of Intrusive Memories.Neuropsychobiology · 2026Article
- Menstrual Cycle and Athletic Status Interact to Influence Symptoms, Mood, and Cognition in Females.Sports medicine - open · 2025Article
- Effects of maternal exposure to exogenous progesterone during pregnancy on offspring neurodevelopment.BMC pediatrics · 2025Observational
- Current View on PPAR-α and Its Relation to Neurosteroids in Alzheimer's Disease and Other Neuropsychiatric Disorders: Promising Targets in a Therapeutic Strategy.International journal of molecular sciences · 2024Review
- Premenstrual syndrome: new insights into etiology and review of treatment methods.Frontiers in psychiatry · 2024Review
- Progesterone and Its Metabolites Play a Beneficial Role in Affect Regulation in the Female Brain.Pharmaceuticals (Basel, Switzerland) · 2023Review
- The Prominent Role of the Temporal Lobe in Premenstrual Syndrome and Premenstrual Dysphoric Disorder: Evidence From Multimodal Neuroimaging.Frontiers in psychiatry · 2022Review
- Article
- Menopause, hormone therapy and cognition: maximizing translation from preclinical research.Climacteric : the journal of the International Menopause Society · 2021Review
- Friend vs. Foe: Cognitive and Affective Empathy in Women With Different Hormonal States.Frontiers in neuroscience · 2021Article
- Psychoactive properties of BNN27, a novel neurosteroid derivate, in male and female rats.Psychopharmacology · 2020Article
- Females' menstrual cycle and incentive salience: Insights on neural reaction towards erotic pictures and effects of gonadal hormones.Comprehensive psychoneuroendocrinology · 2020Article
- Response to nicotine following overnight smoking abstinence during short-term progesterone treatment in women.Experimental and clinical psychopharmacology · 2020Article
- GABA-A receptor modulating steroids in acute and chronic stress; relevance for cognition and dementia?Neurobiology of stress · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Progesterone, or rather its neuroactive metabolite allopregnanolone, modulates amygdala activity and thereby influences anxiety. Cognition and, in particular, memory are also altered by allopregnanolone. In the present study, we investigated whether allopregnanolone modulates memory for biologically salient stimuli by influencing amygdala activity, which in turn may affect neural processes in other brain regions. A single progesterone dose was administered orally to healthy young women in a double-blind, placebo-controlled, crossover design, and participants were asked to memorize and recognize faces while undergoing functional magnetic resonance imaging. Progesterone decreased recognition accuracy without affecting reaction times. The imaging results show that the amygdala, hippocampus, and fusiform gyrus supported memory formation. Importantly, progesterone decreased responses to faces in the amygdala and fusiform gyrus during memory encoding, whereas it increased hippocampal responses. The progesterone-induced decrease in neural activity in the amygdala and fusiform gyrus predicted the decrease in memory performance across subjects. However, progesterone did not modulate the differential activation between subsequently remembered and subsequently forgotten faces in these areas. A similar pattern of results was observed in the fusiform gyrus and prefrontal cortex during memory retrieval. These results suggest that allopregnanolone impairs memory by reducing the recruitment of those brain regions that support memory formation and retrieval. Given the important role of the amygdala in the modulation of memory, these results suggest that allopregnanolone alters memory by influencing amygdala activity, which in turn may affect memory processes in other brain regions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.