ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Behavioral discrimination between sucrose and other natural sweeteners in mice: implications for the neural coding of T1R ligands.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 46 citations in OpenAlex.
- Article
- The contributions of taste cues to ethanol responses in female and male rats.Physiology & behavior · 2025Article
- Sugar type and route of delivery influence insulin and glucose-dependent insulinotropic polypeptide responses in rats.American journal of physiology. Endocrinology and metabolism · 2025Article
- Exogenous oral application of PYY and exendin-4 impacts upon taste-related behavior and taste perception in wild-type mice.Neuropharmacology · 2025Article
- Dietary experience with glucose and fructose fosters heightened avidity for glucose-containing sugars independent of TRPM5 taste transduction in mice.Nutritional neuroscience · 2023Article
- The elusive cephalic phase insulin response: triggers, mechanisms, and functions.Physiological reviews · 2023Review
- Dietary butyrate ameliorates metabolic health associated with selective proliferation of gut Lachnospiraceae bacterium 28-4.JCI insight · 2023Article
- Effect of early-life stress or fluoxetine exposure on later-life conditioned taste aversion learning in Sprague-Dawley rats.Neuroscience letters · 2022Article
- Characterization of Taste Compounds and Sensory Evaluation of Soup Cooked with Sheep Tail Fat and Prickly Ash.Foods (Basel, Switzerland) · 2022Article
- Assessment of Taste Function.Handbook of experimental pharmacology · 2022Article
- Y1 receptors modulate taste-related behavioral responsiveness in male mice to prototypical gustatory stimuli.Hormones and behavior · 2021Article
- Diabetes type 2 risk gene Dusp8 is associated with altered sucrose reward behavior in mice and humans.Brain and behavior · 2021Article
- The Role of Post-Ingestive Feedback in the Development of an Enhanced Appetite for the Orosensory Properties of Glucose over Fructose in Rats.Nutrients · 2020Article
- Sweet and bitter taste stimuli activate VTA projection neurons in the parabrachial nucleus.Brain research · 2019Article
- T1R2+T1R3-independent chemosensory inputs contributing to behavioral discrimination of sugars in mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Behavioral evidence that select carbohydrate stimuli activate T1R-independent receptor mechanisms.Appetite · 2018Article
- Cross-Generalization Profile to Orosensory Stimuli of Rats Conditioned to Avoid a High Fat/High Sugar Diet.Chemical senses · 2018Article
- Behavioral Evidence for More than One Taste Signaling Pathway for Sugars in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Behavioral analyses of taste function and ingestion in rodent models.Physiology & behavior · 2015Article
- Mice perceive synergistic umami mixtures as tasting sweet.Chemical senses · 2015Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
In taste bud cells, two different T1R heteromeric taste receptors mediate signal transduction of sugars (the canonical "sweet" taste receptor, T1R2 + T1R3) and L-amino acids (the T1R1 + T1R3 receptor). The T1R1 + T1R3 receptor is thought to mediate what is considered the fifth basic taste quality "umami." However, a subset of L-amino acids is "sweet tasting" to humans and appears to possess a "sucrose-like" taste quality to nonhuman mammals. This suggests, to varying degrees, that all of these compounds activate a single neural channel that leads to the perception of sweetness. The experiments detailed here were designed to test the ability of mice to distinguish between sucrose and various others sugars and L-amino acids in operant taste discrimination tasks. Mice had at least some difficulty discriminating sucrose from L-serine, L-threonine, maltose, fructose, and glucose. For example, when concentration effects are taken into consideration, mice discriminated poorly, if at all, sucrose from glucose or fructose and, to a lesser extent maltose, suggesting that sugars generate a unitary perceptual quality. However, mice were able to reliably discriminate sucrose from L-serine and L-threonine. Data gathered using a conditioned taste aversion assay also suggest that, although qualitatively similar to the taste of sucrose, L-serine and L-threonine generate distinctive percepts. In conclusion, it appears that some signals from taste receptor proteins binding with sugars and some L-amino acids converge somewhere along the gustatory neuraxis. However, the results of these experiments also imply that sweet-tasting L-amino acids may possess qualitative taste characteristics that are distinguishable from the prototypical sweetener sucrose.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.